Self-Stirring Drives Solid-State Suzuki–Miyaura Reaction with Real-Time Visualization

Le résumé fourni par la source

Solid-state cross-coupling is a promising synthetic strategy, enabling green processes and access to otherwise unattainable products. Inspired by the fundamental diffusion dynamics observed in nature, we developed a polymeric palladium-catalyzed solid-state Suzuki–Miyaura reaction that proceeds without mechanical input, that is, self-stirring of the components results from heat-induced convection-driven mass transfer. This approach enabled the synthesis of various polycyclic aromatic hydrocarbons and functional materials in yields of up to 93% with Pd loadings as low as 500 mol ppm Pd. Notably, the self-stirring behavior of the reaction was observed in real time, revealing interactions between water droplets, the inorganic base, and the arylboronic acid that generated a reactive boronate intermediate, promoting the reaction in the presence of the aryl halide and Pd catalyst.

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