Integrated transcriptomic and metabolomic analysis identifies host response mechanisms to oncogenic Marek’s disease virus in Wenchang chickens
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Le résumé fourni par la source
Marek's disease (MD), caused by Marek's disease virus (MDV), poses a significant threat to the poultry industry worldwide by inducing neurological disorders and malignant lymphoma in infected chickens. The underlying mechanisms of the host response to MDV infection and tumorigenesis remain poorly understood. To gain insight into the host response, we analysed the transcriptomic and metabolomic profiles of the heart tissue of Wenchang chickens, an indigenous Chinese breed, using RNA sequencing and untargeted metabolomics. A total of 2470 and 2666 genes were significantly up- and down-regulated, respectively, between infected and uninfected chickens. KEGG pathway enrichment analysis revealed distinct transcriptional patterns in response to MDV infection: upregulated genes were enriched primarily in immunity-related pathways, whereas downregulated genes were associated with metabolic pathways. Among the 433 differentially expressed metabolites identified, only the caffeine metabolism pathway approached statistical significance (p = 0.067). Integrative mapping of genes and metabolites to the KEGG enzyme database highlighted L-tryptophan interactions, with KYNU, KMO, KYAT3, and AADAT as the most representative relationships. These results provide a quantitative overview of MDV-induced transcriptional and metabolic perturbations, suggesting that hosts may counteract viral infection and tumor progression by suppressing cellular metabolism to potentiate immune responses.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Integrated transcriptomic and metabolomic analysis identifies host response mechanisms to oncogenic Marek’s disease virus in Wenchang chickens
- Date Crossref
- 07/10/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese Academy of Tropical Agricultural Sciences pays non établi dans la noticeOrganisme public
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Tropical Crops Genetic Resources Institute pays non établi dans la noticeStructure de recherche
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Hubei Normal University pays non établi dans la noticeUniversité ou école supérieure
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College of Life Sciences Huangshi Biomedicine Industry and Technology Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Key Lab of Tropical Crops Information Technology Application Research of Hainan Province pays non établi dans la noticeStructure de recherche
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Agriculture and Rural Affairs Bureau of Yangxin County pays non établi dans la noticeInstitution
Chinese Academy of Tropical Agricultural Sciences, Tropical Crops Genetic Resources Institute et Hubei Normal University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.