Supplementary Figures S1-S5 from Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis

Le résumé fourni par la source

The supplementary figure file includes Figures S1–S5. Descriptions of each figure are as follows: - Figure S1 shows the approach for editing the 7p14.3 locus in PC3 cells. - Figure S2 shows differential gene expression in bulk and in single clones of PC3 edited cells - Figure S3 shows the impact of single nucleotide editing on Gli3 targets Gli1 and PTCH1, and how Hh inhibitor cyclopamine prevents the accumulation of Gli3 targets. - Figure S4 shows the impact of SPOP status on CYP11A1 expression in LNCaP and 22Rv1 cells. - Figure S5 shows how SPOP status affects PR accumulation in LNCaP and PC3 cells, and how single nucleotide editing influences SRD5A1 and 3BHSD2 expression.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.