Inflammatory Cytokine Signatures Are Associated With Disease Burden and Comorbidity of Episodic Migraine and Endometriosis
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Le résumé fourni par la source
OBJECTIVES: The aim of this study was to characterize inflammatory cytokine profiles in women diagnosed with episodic migraine, endometriosis, or both conditions and to determine how these cytokine patterns relate to symptom severity and functional impact, to identify potential biological markers distinguishing comorbid cases from single-diagnosis cases. METHODS: Female patients with only episodic migraine, only endometriosis, or both conditions were enrolled. Plasma levels of proinflammatory cytokines were measured, and correlations with clinical parameters were analyzed. RESULTS: Women with episodic migraine had elevated levels of IL-1β, IL-6, and TNF-α compared with healthy controls, with even higher levels in those with both migraine and endometriosis, indicating a synergistic effect on systemic inflammation. IL-1β correlated with headache frequency and disability while IL-6 and TNF-α were linked to migraine severity and pain. Women with endometriosis alone did not show similar cytokine elevations, suggesting that inflammation is particularly amplified in comorbidity. Changes in leukocyte distribution further supported a unique immune activation profile in the comorbid group. DISCUSSION: These findings reveal novel biological evidence of a shared inflammatory endotype in women suffering from both conditions, which may contribute to the increased burden and comorbidity, highlighting the need for integrative diagnostic and management approaches.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Inflammatory Cytokine Signatures Are Associated With Disease Burden and Comorbidity of Episodic Migraine and Endometriosis
- Date Crossref
- 01/11/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Rome Tor Vergata Department of Systems Medicine pays non établi dans la noticeUniversité ou école supérieure
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Istituto di Farmacologia Traslazionale pays non établi dans la noticeStructure de recherche
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Fondazione Santa Lucia pays non établi dans la noticeÉtablissement de santé
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National Research Council pays non établi dans la noticeOrganisation à but non lucratif
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Tor Vergata University Hospital Neurology Unit pays non établi dans la noticeUniversité ou école supérieure
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Institute of Translational Pharmacology pays non établi dans la noticeStructure de recherche
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Laboratory of Resolution of Neuroinflammation pays non établi dans la noticeStructure de recherche
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Laboratory of Experimental Neuroscience pays non établi dans la noticeStructure de recherche
Department of Systems Medicine — University of Rome Tor Vergata, Istituto di Farmacologia Traslazionale et Fondazione Santa Lucia, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.