Kinetics of Serum Myoglobin and Creatine Kinase Related to Exercise-Induced Muscle Damage and ACTN3 Polymorphism in Military Paratroopers Under Intense Exercise
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Le résumé fourni par la source
Background: Physical conditioning is essential to meet the operational demands of military environments. However, high-intensity exercise provokes muscle microinjuries resulting in exercise-induced muscle damage. This condition is typically monitored using serum biomarkers such as creatine kinase (CK), myoglobin (MYO), and lactate dehydrogenase (LDH). Nevertheless, individual variability and genetic factors complicate the interpretation. In this context, the rs1815739 variant (ACTN3), the most common variant related to exercise phenotypes, hypothetically could interfere with the muscle physiological response. This study aimed to evaluate the kinetics of serum biomarkers during a high-intensity activity and their potential association with rs1815739 polymorphism. Materials and Methods: 32 male cadets were selected during the Army Paratrooper Course. Serum was obtained at six distinct moments while they performed regular course tests and recovery time. Borg scale was assessed in 2 moments (~11 and ~17). Results: Serum levels of CK, CK-MB, MYO, and LDH significantly increase after exercise, proportionally to Borg’s level, following the applicability of longitudinal studies to understand biomarker levels in response to exercise. R allele carriers (ACTN3) were only slightly associated with greater levels of MYO and CK, mainly in relative kinetic levels, and especially at moments of greater physical demand/recovery. Although the ACTN3 was slightly related to different biomarker levels in our investigation, the success or healthiness in military activities is multifactorial and does not depend only on interindividual variability or physical capacity. Conclusions: Monitoring biomarkers and multiple genomic regions can generate more efficient exercise-related phenotype interventions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Kinetics of Serum Myoglobin and Creatine Kinase Related to Exercise-Induced Muscle Damage and ACTN3 Polymorphism in Military Paratroopers Under Intense Exercise
- Date Crossref
- 02/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto de Biologia do Exército pays non établi dans la noticeStructure de recherche
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Escola de Comando e Estado-Maior do Exército pays non établi dans la noticeUniversité ou école supérieure
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Exército Brasileiro pays non établi dans la noticeOrganisme public
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Universidade Federal do Rio de Janeiro pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal do Estado do Rio de Janeiro pays non établi dans la noticeUniversité ou école supérieure
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Clinical Analyses Laboratory pays non établi dans la noticeStructure de recherche
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Molecular Diagnostic Laboratory pays non établi dans la noticeStructure de recherche
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School of Physical Education and Sport Department of Running pays non établi dans la noticeUniversité ou école supérieure
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Teaching Division pays non établi dans la noticeInstitution
Instituto de Biologia do Exército, Escola de Comando e Estado-Maior do Exército et Exército Brasileiro, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.