Profile of suicides in a spanish cohort of people living with HIV (PLWH)

Le résumé fourni par la source

• Suicide rates among PLWH in Spain decreased after 2015. • Psychiatric non-AIDS events were prevalent in suicide cases. • Higher suicide risk linked to injection drug use among PLWH. • Integrase inhibitors may contribute to declining suicide rates. • Suicide prevention programs are crucial for vulnerable PLWH. People living with HIV (PLWH) face a higher risk of suicide compared to the general population. Understanding the incidence and characteristics of suicide in this population is essential to design effective prevention strategies. This study aimed to estimate the incidence rate of suicide among PLWH in Spain and to describe the demographic, clinical, and treatment-related profiles of affected individuals. A retrospective cohort study was conducted using data from the CoRIS cohort, including 19,352 PLWH followed from January 2004 to December 2022. Sociodemographic, clinical, and virological data were analyzed, and suicide incidence rates were calculated per 100,000 person-years. Over 134,375 person-years, 22 suicides were recorded, corresponding to an incidence rate of 16.37 per 100,000 person-years (95% CI: 10.26-24.79). Most cases (90.9%) occurred in men, with a mean age of 37.7 years. A higher proportion of injection drug use (18.2% vs. 6.4%) and psychiatric non-AIDS events, including depression and previous suicide attempts, were noted among suicide cases. The suicide incidence rate decreased significantly after 2015, coinciding with the broader use of integrase inhibitors. The suicide incidence rate among PLWH in Spain has declined in recent years, approaching levels observed in the general population. However, targeted interventions are needed to address mental health challenges and enhance support for vulnerable individuals within this population.

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