Unraveling key molecules mediating the mechanisms of YAP deletion or inhibition in liver fibrosis regression through a multi-omics approach.
Rattachement africain : cn, us, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: This study aimed to identify key molecules that potentially mediate the mechanisms by which YAP deletion or inhibition attenuates liver fibrosis. MATERIALS AND METHODS: -verteporfin (VP). RNA sequencing (RNA-seq) and proteomic analysis were conducted. Immunohistochemistry and western blotting were also performed to verify the differentially expressed genes (DEGs) identified through the multi-omics approach. Human subjects were enrolled to further assess the identified DEGs. RESULTS: group. Furthermore, plasma p62, HSP27, and HSP70 levels were increased with the occurrence of chronic hepatitis B and HBV-related cirrhosis, whereas MFGE8 levels were decreased. Spearman's correlation analysis further illustrated a significant association between these biomarkers and YAP levels. CONCLUSIONS: This study identified HSP27, HSP70, p62, and MFGE8 as crucial YAP-related molecules involved in liver fibrosis.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
Où se fait cette recherche
-
Bengbu Medical College pays non établi dans la noticeUniversité ou école supérieure
-
National Clinical Research Center for Digestive Diseases pays non établi dans la noticeÉtablissement de santé
-
National Clinical Research pays non établi dans la noticeStructure de recherche
-
First Affiliated Hospital of Bengbu Medical College pays non établi dans la noticeÉtablissement de santé
-
Institute of Infection and Immunity pays non établi dans la noticeStructure de recherche
-
The First Affiliated Hospital of Bengbu Medical University Department of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
-
Key Laboratory of Infection and Immunity of Anhui Province pays non établi dans la noticeStructure de recherche
Bengbu Medical College, National Clinical Research Center for Digestive Diseases et National Clinical Research, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.