Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study
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Le résumé fourni par la source
Background: Distinguishing bipolar disorder (BD) from unipolar depression (UD) remains a critical clinical challenge. Improved diagnostic accuracy could enhance therapeutic outcomes for both conditions. This study aims to (1) identify functional near-infrared spectroscopy (fNIRS)-based biomarkers differentiating BD from UD, and (2) compare frontotemporal hemodynamic responses during phonological (LFT) and semantic (CFT) verbal fluency tasks. Methods: We recruited 100 participants: 33 with UD, 34 with BD, and 33 healthy controls (HC). Cortical oxygenation changes ([oxy-Hb]) were recorded using 52-channel fNIRS during LFT and CFT performance. Findings: The [oxy-Hb] activation in the UD and BD groups was lower compared to the HC group. Most channels demonstrated the [oxy-Hb] activation is lowest in BD patients, followed by UD patients, and the highest in the HC participants. Compared to CFT, UD and HC patients exhibited more extensive prefrontal cortex activation during LFT. This study found differences in [oxy-Hb] activation in the ventrolateral prefrontal cortex (VLPFC) between BD and UD patients during the CFT period. Conclusion: Our findings indicate that the LFT elicits more extensive prefrontal activation, with differential engagement of the VLPFC in BD compared to UD. These results suggest potential neuroimaging biomarkers for distinguishing between UD and BD, while also providing insights into the neural substrates of language processing.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study
- Date Crossref
- 25/09/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Henan Psychiatric Hospital pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Xinxiang Medical University Henan Key Laboratory of Neurorestoratology pays non établi dans la noticeÉtablissement de santé
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Shandong Mental Health Center pays non établi dans la noticeÉtablissement de santé
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Henan Engineering Research Center of Physical Diagnostics and Treatment Technology for the Mental and Neurological Diseases pays non établi dans la noticeStructure de recherche
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The Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital) pays non établi dans la noticeUniversité ou école supérieure
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Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders pays non établi dans la noticeInstitution
Henan Psychiatric Hospital, Henan Key Laboratory of Neurorestoratology — First Affiliated Hospital of Xinxiang Medical University et Shandong Mental Health Center, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.