The Association of Mild Kidney Disease With Coronary Artery Disease Is Stronger for People Living With HIV
Rattachement africain : us, Ouganda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To examine the association between mild kidney disease and coronary plaque parameters using coronary computed tomography angiography in people living with HIV (PWH) compared with people without HIV in Uganda. DESIGN: Cross-sectional secondary analysis. METHODS: We studied 165 participants aged >45 years with ≥1 cardiovascular risk factor (78 PWH on stable antiretroviral therapy, 87 HIV-negative). Kidney function was assessed using estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR). Coronary artery disease (CAD) was characterized by segment involvement score (SIS), segment stenosis score (SSS), and coronary artery calcium score. Multivariable Tobit regression assessed associations of kidney function measures with CAD parameters, testing for differences by HIV status. RESULTS: The median (interquartile range) age was 57.0 (53-62) years, 62.4% of subjects were female, and 87.3% had hypertension. Among PWH, mildly impaired eGFR (<90 mL/min/1.73 m2) was associated with higher SIS [β 3.31, 95% confidence interval (CI): 0.41 to 6.21, P = 0.03] and SSS (β 5.95, 95% CI: 0.54 to 11.36, P = 0.03). The association with SIS remained significant after adjusting for age, gender, and 10-year ASCVD score (β 2.58, 95% CI: 0.10 to 5.06, P = 0.04). Associations of ACR with coronary plaque were not statistically significant for participants with or without HIV (all P > 0.07). CONCLUSION: In PWH, mildly reduced eGFR was associated with greater coronary plaque burden (SIS, SSS) but not coronary artery calcium; ACR showed no associations with any CAD measures. Incorporating kidney function measures into cardiovascular risk assessment may be valuable in HIV care.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Association of Mild Kidney Disease With Coronary Artery Disease Is Stronger for People Living With HIV
- Date Crossref
- 01/01/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Washington Department of Global Health pays non établi dans la noticeUniversité ou école supérieure
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Infectious Disease Research Institute pays non établi dans la noticeOrganisation à but non lucratif
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Fred Hutch Cancer Center pays non établi dans la noticeOrganisation à but non lucratif
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Cancer Research Center Vaccine and Infectious Disease Division pays non établi dans la noticeOrganisation à but non lucratif
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Joint Clinical Research Centre Kampala, Ouganda (code pays fourni par la source)Organisation à but non lucratif
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University of Pittsburgh Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Nsambya Hospital Department of Radiology Kampala, Ouganda (code pays fourni par la source)Établissement de santé
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Makerere University Department of Radiology Makerere University, Ouganda (code pays fourni par la source)Université ou école supérieure
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New York University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Global Health pays non établi dans la noticeInstitution
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Medicine pays non établi dans la noticeInstitution
Department of Global Health — University of Washington, Infectious Disease Research Institute et Fred Hutch Cancer Center, avec 8 autres affiliations. Pays d’affiliation : Ouganda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.