Accès ouvert déclaré 2025 article

Seroprevalence of IgG antibodies against hepatitis-A infection among individuals aged 6–30 years in India, 2021: a nationwide population-based cross-sectional study

Muthusamy Santhosh Kumar, C. P. Girish Kumar, Saravanakumar Velusamy, Thiyagarajan Karunakaran, Jeromie Wesley Vivian Thangaraj, Sriram Selvaraju, Kiran Rade, Ramasamy Sabarinathan, S Parvathi, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Jyothi Bhat, Debjit Chakraborty, Vishal Chopra, Dasarathi Das, Kangjam Rekha Devi, Gaurav Raj Dwivedi, Muhammad Salim Khan, M. Sunil Kumar, Avula Laxmaiah, Major Madhukar, Amarendra Mahapatra, Talluri Ramesh, Chethana Rangaraju, Jyotirmayee Turuk, Suresh Yadav, Tarun Bhatnagar, Balram Bhargava, Manoj Vasanth Murhekar, Alka Turuk, Manjula Singh, Abdul Mabood Khan, Samiran Panda, Nivethitha N. Krishnan, Aby Robinson, Nivetha Srinivasan, Rushikesh Andhalkar, Anshuman Chaudhury, Prathiksha Giridharan, Naga Bhushanam Kotala, Krithikaa Sekar, Surabhi Yadav, Chandrasekaran Padmapriyadarshini, Vikas Dhikav, Ramesh Kumar Sangwan, Mahendra Thakor, Nimmathota Arlappa, Babu Jagjeevan, Hemalatha Rajkumar, Khalid Bashir, Inaamul Haq, Mariya Amin Qurieshi, Praveen K. Bharti, Pushpendra Singh, Debdutta Bhattacharya, Srikanta Kanungo, Jaya Singh Kshatri, Subrata Kumar Palo, Sanghamitra Pati, Rajni Kant, Hirawati Deval, Niraj Kumar, Rajeev K Singh, Sthita Pragnya Behera, Ashok Kumar Pandey, Ashrafjit S. Chahal, Alok Kumar Deb, Shanta Dutta, Sarang V. Dhatrak, Ankit Viramgami, Amit Kumar Chakrabarti, R. S. Dayal, Anindya Mitra, Arshad Kalliath, A Kalaiselvan, Senthil Kumar Mayandi, Sreelakshmy Thalappil Naduvilethil, Neelima Devi Akula, Bhuvaneswari Anandhan, Sekar Dhanapriya Vadhani, M. Anbu, Prashant Kumar Singh, Shalini Singh, Hari Bhan Singh, Agam Jain, A.R. Nirmala, Seema Sahay, Kanwar Narain, Somashekar Narasimhaiah, Krishna Pandey

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19Institutions déclarées

1Pays d’affiliation déclarés

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Le résumé fourni par la source

Background: India accounts for one-fifth of the global hepatitis A virus (HAV) infections and half of HAV-related deaths. There is a lack of nationally representative population-based data on the endemicity of HAV to inform vaccination policy. We aimed to estimate the age-specific seroprevalence of HAV infection among individuals aged 6-30 years. Methods: We used serum samples collected during the fourth national COVID-19 serosurvey conducted between 14 June and 6 July 2021 to estimate the seroprevalence of HAV infection. The survey was conducted in 70 randomly selected districts across 20 Indian states and one union territory. We tested the serum samples from individuals aged six to 30 years for IgG antibodies against HAV. We estimated the overall and state-specific seroprevalence, along with 95% CIs, for the age groups of 6-10, 11-15 and 16-30 years. We classified the HAV endemicity in India using WHO classification (high, intermediate, low and very low). Findings: We tested 14,778 serum samples from individuals aged six to 30 years for IgG antibodies against HAV. Of these, 12,236 (90.0%, 95% CI 88.5-91.4) were found to be reactive. The seroprevalence increased with age, from 74.7% (71.1-77.9) among children aged 6-10 years to 85.2% (82.7-87.4) among those aged 11-15 years and 96.9% (96.3-97.5) among individuals aged 16-30 years. India was categorized as having intermediate endemicity for HAV infection as per the WHO classification. Of the 21 states or union territories included in the survey, 18 had intermediate endemicity. Interpretation: Our study findings indicate an intermediate level of endemicity for HAV infection in India. While these findings support consideration of hepatitis-A vaccination, further evidence on disease burden and cost-effectiveness is needed to inform policy decisions. Funding: Gates Foundation & Indian Council of Medical Research.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Seroprevalence of IgG antibodies against hepatitis-A infection among individuals aged 6–30 years in India, 2021: a nationwide population-based cross-sectional study
Date Crossref: 01/10/2025
Éditeur: Elsevier BV
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Software Training and Development Centre pays non établi dans la notice
Université ou école supérieure
National Institute of Epidemiology pays non établi dans la notice
Structure de recherche
National Institute of Research in Tuberculosis pays non établi dans la notice
Structure de recherche
World Health Organization - India pays non établi dans la notice
Organisme public
National Institute of Cancer Prevention and Research pays non établi dans la notice
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National Institute of Occupational Health pays non établi dans la notice
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National AIDS Research Institute pays non établi dans la notice
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National JALMA Institute for Leprosy & Other Mycobacterial Diseases pays non établi dans la notice
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National Institute for Research in Tribal Health pays non établi dans la notice
Établissement de santé
Regional Medical Research Centre pays non établi dans la notice
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Baba Raghav Das Medical College pays non établi dans la notice
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Government Medical College pays non établi dans la notice
Université ou école supérieure

Software Training and Development Centre, National Institute of Epidemiology et National Institute of Research in Tuberculosis, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Hepatitis Viruses Studies and EpidemiologyViral gastroenteritis research and epidemiologyHepatitis B Virus Studies

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