Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness
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Le résumé fourni par la source
BACKGROUND: Atelectasis frequently occurs in patients with impaired consciousness who are being treated with invasive mechanical ventilation. It is mainly caused by secretion accumulation, which can lead to longer durations of ventilation and ICU stay. RESEARCH QUESTION: Does continuous high-frequency oscillation (CHFO) therapy improve lung aeration and reduce atelectasis in adults with impaired consciousness who are mechanically ventilated? STUDY DESIGN AND METHODS: This multicenter, single-anonymized, randomized controlled trial was conducted across 11 hospitals in China. Adult patients with impaired consciousness (Glasgow Coma Scale score ≤ 8) who required invasive mechanical ventilation were randomly assigned in a 1:1 ratio to either the CHFO or usual care group. The CHFO group received 3 to 4 sessions daily. The primary outcome was the percent change in nonaerated lung tissue, measured by CT scan, from baseline to day 5, as analyzed in the intention-to-treat population. RESULTS: From June 19, 2023, to July 2, 2024, a total of 80 patients were included in the intention-to-treat analysis. Five patients from each group were excluded from the primary analysis due to incomplete CT scans. On day 5, the decrease in nonaerated lung tissue was greater in the CHFO group (-51.3%; 95% CI, -62.7 to -40.0) compared with the usual care group (-37.6%; 95% CI, -49.3 to -26.0), with a mean difference of -13.69% (95% CI, -24.86 to -2.52; P = .017). The CHFO group also had a higher number of ventilator-free days, a lower clinical pulmonary infection score, and a shorter ICU stay. No adverse events of interest were observed during the study. INTERPRETATION: In patients with impaired consciousness who are mechanically ventilated, 5 days of CHFO treatment was shown to significantly reduce nonaerated lung tissue. CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry; No.: ChiCTR2300070988; https://www.chictr.org.cn.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness
- Date Crossref
- 01/03/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Zhongda Hospital Southeast University Jiangsu Provincial Key Laboratory of Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Nantong University pays non établi dans la noticeUniversité ou école supérieure
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Taizhou People's Hospital Department of Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Nanjing Medical University pays non établi dans la noticeUniversité ou école supérieure
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University of Science and Technology of China Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Northern Jiangsu People's Hospital Department of Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Yangzhou University Intensive Care Unit pays non établi dans la noticeUniversité ou école supérieure
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Xuzhou Central Hospital pays non établi dans la noticeÉtablissement de santé
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Westlake University Affiliated Hangzhou First People's Hospital pays non établi dans la noticeÉtablissement de santé
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Wannan Medical College Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Wannan Medical College pays non établi dans la noticeÉtablissement de santé
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Central South University Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
Jiangsu Provincial Key Laboratory of Critical Care Medicine — Zhongda Hospital Southeast University, Nantong University et Department of Intensive Care Unit — Taizhou People's Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.