Stratifying atherosclerotic cardiovascular disease by SMuRF burden in a Middle-Eastern country: A multiregistry study of demographics, comorbidities, and therapeutic trends
Rattachement africain : jo, au, sa, kw, qa, ae. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a growing public health challenge in the Middle East, driven by increasing rates of obesity, diabetes, and hypertension. However, limited region-specific data exist on the distribution and impact of Standard Modifiable Risk Factors (SMuRFs) among affected individuals. Most available evidence is derived from Western populations, which may not reflect the unique demographic, cultural, and epidemiological profiles of Middle Eastern communities. OBJECTIVE: This study aims to compare demographic profiles, clinical presentations, comorbidities, and pharmacologic management among Middle Eastern patients with ASCVD, stratified by SMuRF burden: SMuRF-less (no risk factors), 1-2 SMuRFs, and 3-4 SMuRFs. The goal is to identify clinically relevant differences across these groups and address the significant gap in region-specific data on ASCVD risk factors and outcomes. METHODS: Data were pooled from six established cardiovascular registries and the Jordan SMuRF-less patient study. Baseline characteristics, cardiovascular risk profiles, comorbidities, use of secondary prevention therapies, and one-year outcomes were analyzed across the three SMuRF categories. RESULTS: Among 5,540 patients, the group with 3-4 SMuRFs exhibited the highest prevalence of hypertension (88.9%), diabetes (35.4%), smoking (54.0%), and a family history of cardiovascular disease (39.3%). This group also showed increased rates of chronic kidney disease (7.3%) and heart failure (15.1%). Statin, aspirin, and beta-blocker use increased in parallel with SMuRF burden. Key lipid profiles deteriorated with increasing SMuRFs, with the highest LDL cholesterol observed in patients with 1-2 SMuRFs. CONCLUSIONS: This study provides valuable insight into the clinical characteristics and management patterns of Middle Eastern patients with atherosclerotic cardiovascular disease (ASCVD), stratified according to the burden of standard modifiable risk factors (SMuRFs). An increased SMuRF burden was associated with a higher prevalence of comorbid conditions, including hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and heart failure. Utilizing data from six regional registries, this study represents the first comprehensive, region-specific analysis of the role of modifiable risk factors in this population. The findings underscore the critical need for individualized, risk-based prevention and management strategies to mitigate the rising burden of ASCVD across the Middle East.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Stratifying atherosclerotic cardiovascular disease by SMuRF burden in a Middle-Eastern country: A multiregistry study of demographics, comorbidities, and therapeutic trends
- Date Crossref
- 22/09/2025
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Yarmouk University Nursing Department pays non établi dans la noticeUniversité ou école supérieure
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Flinders University pays non établi dans la noticeUniversité ou école supérieure
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King Saud University Community and Psychiatric Mental Health pays non établi dans la noticeUniversité ou école supérieure
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University of Ha'il pays non établi dans la noticeUniversité ou école supérieure
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Public Authority for Applied Education and Training pays non établi dans la noticeUniversité ou école supérieure
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Jordan University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Jordan Hospital pays non établi dans la noticeÉtablissement de santé
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Qatar University pays non établi dans la noticeUniversité ou école supérieure
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Mohammed Bin Rashid University of Medicine and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Nursing pays non établi dans la noticeUniversité ou école supérieure
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College of Nursing and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Nursing Department — Yarmouk University, Flinders University et Community and Psychiatric Mental Health — King Saud University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.