Prevalence and risk factors of cognitive frailty in people with HIV
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Le résumé fourni par la source
BACKGROUND: Cognitive frailty (CF, the simultaneous presence of frailty and cognitive impairment) is recognized as a significant predictor of several adverse health outcomes. The objective of this study was to describe prevalence and risk factors for CF in people with HIV (PWH) >50 years. METHODS: This was a cross-sectional observational study including PWH attending Modena HIV Metabolic Clinic (MHMC). Neurocognitive function was measured with Cogstate battery that comprises six domains. Each individual CogState raw score was transformed into z-score after correction for age and sex. Neurocognitive impairment was defined by total global deficit score >0.5. Frailty was assessed by 37-Item frailty index. Scores <0.25 were considered fit or >0.26 as frail. RESULTS: A total of 1258 PWH were included, 916 (73%) were males, median age was 58 years, median time since HIV diagnosis was 27 years. The sample was divided into four groups (CF) based on the presence of frailty (F) and cognitive impairment (ICT): F+/ICT+, F+/ICT-, F-/ICT+, F-/ICT-. Age per 5-year increase [odds ratio (OR) = 1.27, confidence interval (CI): 1.02-1.55, P = 0.022], nadir CD4 + cell count (OR = 0.81, CI: 0.66 - 0.99, P = 0.042) and polypharmacy (OR = 3.47, CI: 2.00-6.00, P < 0.001) were associated with CF after adjustment for time since HIV diagnosis, multimorbidity, depression and cumulative exposure to dolutegravir. CONCLUSION: CF prevalence in PWH >50 years was 6.8% and it is higher than what has been observed in the general population >65 years (1-4.4%). Nadir CD4 + cell count and polypharmacy was associated with CF, suggesting an HIV specific contribution related to the development of this condition.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and risk factors of cognitive frailty in people with HIV
- Date Crossref
- 24/11/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Modena and Reggio Emilia Department of Surgical pays non établi dans la noticeUniversité ou école supérieure
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Brescia University pays non établi dans la noticeUniversité ou école supérieure
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University of Brescia Department of Molecular and Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Indiana University School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Surgical Specialties (Canada) pays non établi dans la noticeEntreprise
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Azienda Ospedaliero-Universitaria di Modena pays non établi dans la noticeÉtablissement de santé
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Ospedale Amedeo di Savoia pays non établi dans la noticeÉtablissement de santé
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Policlinico of Modena Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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University of Torino Unit of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
Department of Surgical — University of Modena and Reggio Emilia, Brescia University et Department of Molecular and Translational Medicine — University of Brescia, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.