Impact of antibiotics on the genomic expression of Pseudomonas aeruginosa in the East African community: a systematic review
Rattachement africain : Ouganda, Rwanda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Antimicrobial resistance (AMR) is a major global health concern, with the greatest burden observed in lower-middle-income countries. Monitoring AMR through a One Health approach is essential to understand the link between clinical, animal, and environmental sources and to develop targeted interventions. Objectives This systematic review aimed to assess the impact of antibiotics on gene expression in Pseudomonas spp. within the East African Community (EAC). Methodology A thorough literature search across Web of Science, Scopus, and PubMed yielded 284 articles, of which 11 met the inclusion criteria after screening. The selected studies came from five EAC countries. Findings showed a high prevalence of AMR in Pseudomonas aeruginosa , with over 90% resistance to most antibiotics, except Amikacin, which remained effective likely due to limited usage. Results and discussion Common resistance genes identified included carbapenemases such as blaNDM-1 and blaVIM. The disc diffusion method was the most commonly used technique (50%).Multidrug-resistant clones like ST244 and ST357 were frequently reported. Environmental isolates had lower resistance rates (54%) compared to clinical strains (73%), suggesting differing selection pressures. Most studies originated from Kenya and Uganda (each 30%), reflecting differences in research capacity and healthcare infrastructure across the region. Conclusion These results underscore the urgent need for expanded AMR surveillance, stronger antimicrobial stewardship, and further research to inform public health responses in East Africa.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of antibiotics on the genomic expression of Pseudomonas aeruginosa in the East African community: a systematic review
- Date Crossref
- 19/09/2025
- Éditeur
- F1000 Research Ltd
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Kampala International University Department of Publications and Extension Kampala International University, Ouganda (code pays fourni par la source)Université ou école supérieure
-
University of Kigali University of Kigali, Rwanda (code pays fourni par la source)Université ou école supérieure
-
School of Allied Health Sciences Department of Medical Laboratory Science Kampala, Ouganda (ville ou établissement reconnu, pays non nommé)Université ou école supérieure
-
Faculty of Biomedical Sciences Department of Microbiology Kampala, Ouganda (ville ou établissement reconnu, pays non nommé)Université ou école supérieure
-
University of Rwanda School of Medicine and Pharmacy Department of Microbiology and parasitology Kigali, Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Publications and Extension — Kampala International University (Kampala International University, Ouganda), University of Kigali (University of Kigali, Rwanda) et Department of Medical Laboratory Science — School of Allied Health Sciences (Kampala, Ouganda), avec 2 autres affiliations. Pays d’affiliation : Ouganda, Rwanda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.