Trends and disparities in mortality from comorbid non-insulin-dependent diabetes mellitus and stroke (1999-2022): A retrospective analysis

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BACKGROUND Comorbid non-insulin-dependent diabetes mellitus (NIDDM) and stroke significantly contribute to mortality among older adults. This study examines age-adjusted mortality rates (AAMRs) and disparities by demographics, region, and age groups to identify trends and guide public health efforts. AIM To analyze trends in AAMRs due to comorbid NIDDM and stroke among older adults. The study aims to identify demographic, geographic, and age-related disparities to inform targeted public health strategies. METHODS Mortality data from the Centers for Disease Control records were analyzed. AAMRs per 100000 and annual percentage changes (APCs) with 95%CI were calculated using Joinpoint Regression RESULTS Between 1999 and 2022, 209001 deaths among adults aged 55+ were attributed to comorbid NIDDM and stroke, with women accounting for 111481 and men 97520 deaths. Urban-rural disparities revealed distinct patterns, with a sharper rise in metropolitan areas post-2014 (APC: 8.6) as compared to non-metropolitan areas. Racial disparities were pronounced, particularly among the Asian/Pacific Islander population, with a steep increase post-2018 (APC: 17.6). Age-stratified analysis showed a marked rise in mortality for ages 55- 64 and 85+ from 2015 onwards (APC: 14.3 and 13.5, respectively). Regional trends highlighted the West as having the highest AAMR (14.4), while the Northeast exhibited the lowest (7.0). State-level analysis showed West Virginia with the highest AAMR (18.7) and Nevada the lowest (3.8). CONCLUSION Rising mortality from comorbid NIDDM and stroke underscores increasing disparities across gender, race, age, and regions. Urgent, tailored interventions are required to mitigate these inequities.

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