Poor Oral Health and Risk of Respiratory Tract Cancer: A Prospective Cohort Study from the UK Biobank

Le résumé fourni par la source

Background/Objectives: The individual and combined effects of diverse dental problems on site-specific respiratory tract cancer remain insufficiently addressed. This study investigated the associations between six oral conditions—dentures, loose teeth, painful gums, bleeding gums, toothache, and mouth ulcers—and the risk of developing cancers of the lung, bronchus, larynx, and trachea, both individually and collectively. Methods: This prospective cohort study, utilizing baseline data from the UK Biobank, analyzed 438,762 participants aged 40–69 years. Multivariable Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% CIs for incident respiratory tract cancer associated with individual oral conditions and their cumulative impact. Effect modification by sociodemographics, lifestyle, and underlying medical conditions was further assessed. Results: During the follow-up (median = 11.0 years), 3568 participants developed respiratory tract cancer. After adjusting for confounders, including smoking history, individuals with any oral issues exhibited a 35–76% higher risk of respiratory tract cancer (HR [95% CI]: 1.35 [1.25–1.46] for the total risk, 1.34 [1.24–1.45] for bronchus/lung cancer, and 1.76 [1.23–2.52] for laryngeal cancer). Dentures (1.48 [1.36–1.60]), loose teeth (1.36 [1.20–1.54]), and painful gums (1.25 [1.04–1.50]) had a strong association with respiratory tract cancer. The overall risk escalated progressively with the number of concurrent problems (HR [95% CI] of 1.32 [1.22–1.43] for one, 1.42 [1.25–1.62] for two, 1.57 [1.23–1.98] for three, and 1.71 [1.16–2.50] for ≥four). Associations were pronounced among smokers (p-interaction = 0.002). Conclusions: Poor oral health is linked to a heightened risk of respiratory tract cancer, especially when coupled with smoking, underscoring the importance of oral health promotion in cancer prevention strategies.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.