Lactate and Hypothermia: A Dual Approach for Neuroprotection in Neonatal Hypoxia-Ischemia

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Motivation: Lactate, a key energy source for neurons, plays a critical role in brain function. Given its importance for neuronal activity, we ask: could it also offer neuroprotection in neonatal hypoxia-ischemia (NHI), a condition characterized by cerebral energy deficits? Goal(s): Nearly half of affected newborns show limited response to current therapeutic hypothermia (TH). This study examines whether combining lactate administration with TH improves neuroprotective outcomes. Approach: Using the Rice-Vannucci model, we optimized TH parameters and conducted MRI, behavioral tests, and protein analysis. Results: Lactate combined with TH showed greater neuroprotective effects, reducing brain lesion volumes and enhancing recovery compared to TH alone. Impact: Lactate administration showed neuroprotection in NHI. Our retrospective clinical evaluation tracking blood parameters during sodium L-lactate infusion in preterm infants confirmed the safety of lactate administration, even with elevated lactatemia at birth, indicating promising potential for clinical pediatric applications.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.