Correlations between regional adipose gene expression and MRI findings in patients with upper or lower extremity lymphedema

Résumé fourni par la source

Motivation: Lymphedema is the accumulation of interstitial fluid in soft tissues and affects approximately 140-200 million worldwide. There is currently a paucity of lymphedema studies that validate gene expression data with MR data. Goal(s): The purpose of our study was to correlate regional adipose gene expression from RNA sequencing with MR-derived features such as fat volume, fluid volume, fat fraction and total subcutaneous area. Approach: This IRB-approved retrospective study in patients with extremity lymphedema correlated MR findings from the affected and contralateral unaffected extremity with RNA sequencing. Results: Our results integrate RNA sequencing data and MR imaging analyses to differentiate lymphedema from normal tissue. Impact: Future applications will evaluate these gene expression patterns and imaging features, including radiomics, in cases of early/equivocal lymphedema to assess gene changes that correlate with duration/severity of disease to provide insight into the natural history and pathophysiology of lymphedema.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.