Meal-induced changes of proton density fat fraction and T2* in supraclavicular adipose tissue

Résumé fourni par la source

Motivation: Investigating brown adipose tissue (BAT) non-invasively has attracted attention as BAT may serve as a target for treating metabolic diseases. Goal(s): To investigate meal-induced changes in activated human BAT. Approach: Ten volunteers received isocaloric meals after fasting (activation experiment). MRI was performed at baseline and one hour post-meal using 12-echo radial stack-of-stars Dixon scans to assess proton density fat fraction (PDFF) and T2*changes. MRI was also performed after fasting without meals (control experiment) at baseline and one hour post-fasting. Results: PDFF and T2* decreased significantly in the activation experiment compared to control. Both parameters showed a simultaneously decreasing trend in the same voxels. Impact: Human brown adipose tissue (BAT) is metabolically activated by meal consumption. Comparing proton density fat fraction (PDFF) and T2* changes between activation and control experiments, this study is the first to give insights into postprandial responses of BAT using MRI.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.