Fixel-based analysis of white matter fiber characteristics and cognitive dysfunction in Alzheimer’s disease

Résumé fourni par la source

Motivation: The relationship between white matter (WM) structure, Alzheimer's disease (AD) progression, and cognitive dysfunction remains unclear. Goal(s): To identify WM fiber differences between healthy controls (HC), mild cognitive impairment (MCI), mild AD, moderate AD, and WM fiber characteristics correlation with cognitive dysfunctions. Approach: Fixel-based analysis (FBA) was used to measure WM fiber density (FD), fiber cross-sectional area (FC), and fiber density and cross-section (FDC) across 27 HC, 19 MCI, 19 mild AD, and 25 moderate AD participants. Results: AD patients showed significant reductions in FD, FC, and FDC in various WM fiber tracts. Some of the reductions also correlated with lower cognitive scores. Impact: This study shows that FBA-measured WM fiber characteristics correlate with AD severity and cognitive decline. These metrics may serve as biomarkers for monitoring disease progression and aiding in the diagnosis of AD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.