Mapping the distribution of neurotransmitters to resting-state functional connectivity in Parkinson’s disease
Rattachement africain : gb, cn, es, us, at, se, pt, pa. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI), 11C-PE2I and 11C-DASB PET, along with comprehensive clinical evaluations of motor and non-motor symptoms. Of these, 15 patients with PD who completed the same assessments after 19 months were included in the longitudinal analysis. rs-fMRI was used to assess functional connectivity, while 11C-PE2I and 11C-DASB PET were used to evaluate interregional homogeneity of dopamine and serotonin levels, referred to as PET covariance. Functional connectivity and PET covariance were estimated using a region-of-interest (ROI)-based approach with 138 ROIs from the Automated Anatomical Labelling 3 atlas, excluding cerebellar regions. These ROIs were further grouped into eight networks: visual, sensorimotor, attention, limbic, frontoparietal, default mode, subcortical and brainstem. At baseline, linear regression revealed that functional connectivity was positively associated with both 11C-PE2I PET covariance (β-values ranging from 0.575 to 0.790, P < 0.001) and 11C-DASB PET covariance (β-values ranging from 0.356 to 0.773, P < 0.001) across all networks. Longitudinally, we found positive correlations between baseline functional connectivity and both 11C-PE2I PET change covariance and 11C-DASB PET change covariance (β-values ranging from 0.166 to 0.576 and 0.312 to 0.671, respectively, P < 0.001) across all networks. These correlations remained significant after controlling for the Euclidean distance between ROIs, indicating that the association is independent of spatial proximity. For both tracers, absolute PET uptake across seed ROIs was positively associated with correspondent regression-derived functional connectivity-PET β-weights, which represent the relationship between PET uptake in target ROIs and their functional connectivity to the seed. This association between target functional connectivity and PET uptake was correlated with PD motor and non-motor severity across different brain regions in a manner that was dependent on the neurotransmitter system evaluated. Our findings suggest that in patients with PD, dopamine and serotonin levels covary among brain regions that are highly functionally connected. This implies that the spatial distribution of these neurotransmitters follows the organizational principles of the brain's functional connectomes, which are associated with features of the disease.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Mapping the distribution of neurotransmitters to resting-state functional connectivity in Parkinson’s disease
- Date Crossref
- 01/01/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Imperial College London Department of Brain Science pays non établi dans la noticeUniversité ou école supérieure
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Beijing University of Posts and Telecommunications pays non établi dans la noticeUniversité ou école supérieure
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Clinica Universidad de Navarra Department of Neurology and Neurosciences pays non établi dans la noticeÉtablissement de santé
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Lung Institute pays non établi dans la noticeÉtablissement de santé
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Invicro (United Kingdom) pays non établi dans la noticeEntreprise
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University of Cambridge Department of Public Health and Primary Care pays non établi dans la noticeUniversité ou école supérieure
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University College London Department of Clinical and Movement Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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Innsbruck Medical University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Royal Gwent Hospital pays non établi dans la noticeÉtablissement de santé
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Cardiff University Neuroscience and Mental Health Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Skåne University Hospital pays non établi dans la noticeÉtablissement de santé
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Lund University Department of Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Brain Science — Imperial College London, Beijing University of Posts and Telecommunications et Department of Neurology and Neurosciences — Clinica Universidad de Navarra, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.