Correlations between receptor occupancy change and mental state in patients using long-acting injectable antipsychotics: MIDILIA pilot study
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Le résumé fourni par la source
Background The rate at which psychosis drugs can be reduced in dose remains unclear. Anecdotal reports exist of people experiencing worsening of mental state before their next dose of long-acting injectable antipsychotic. No research has previously explored this phenomenon, but understanding this may advise on the rate of receptor occupancy change that provokes the emergence of psychotic symptoms. Aims Exploring the relationship between psychotic symptoms and variations in plasma concentration (and calculated receptor occupancy) of long-acting injectable antipsychotics. Method This longitudinal study monitored mental state variation within dosing cycles of people taking depot flupentixol and zuclopenthixol. The Positive and Negative Syndrome Scale (PANSS) monitored global mental state changes, and was stratified into domains according to a five-factor model. Plasma assays at maximal and minimal concentrations allowed prediction of striatal D2 occupancy from published data. We examined correlations between receptor occupancy and the emergence of psychotic symptoms. Results Preliminary results from ten participants with psychotic disorders suggest that global mental state deterioration may correlate with increased rate of D2 occupancy reduction. Increased rate of D2 occupancy reduction led to deterioration in ‘positive’ (r = 0.637 [CI: 0.013, 0.904], P = 0.047) and ‘resistance’ (r = 0.726 [CI: 0.177, 0.930], P = 0.018) PANSS clinical domains at minimal concentrations. PANSS score differences were not related to absolute reduction in D2 occupancy. Conclusions Our novel observational study design has been demonstrated to be feasible and practicable. Faster reductions in D2 occupancy may increase the risk of increased positive psychotic symptoms and irritability. Slower reductions may minimise this effect. Further recruitment is required before this can be confirmed.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Correlations between receptor occupancy change and mental state in patients using long-acting injectable antipsychotics: MIDILIA pilot study
- Date Crossref
- 01/09/2025
- Éditeur
- Royal College of Psychiatrists
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Leeds pays non établi dans la noticeUniversité ou école supérieure
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Leeds and York Partnership NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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South West Yorkshire Partnership NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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King's College London Institute of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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North East London NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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University of Bradford pays non établi dans la noticeUniversité ou école supérieure
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Analytical Services pays non établi dans la noticeOrganisation à but non lucratif
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School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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North East London Foundation Trust pays non établi dans la noticeOrganisation à but non lucratif
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School of Pharmacy and Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Wolfson Centre for Applied Health Research pays non établi dans la noticeInstitution
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Faculty of Health Studies pays non établi dans la noticeUniversité ou école supérieure
University of Leeds, Leeds and York Partnership NHS Foundation Trust et South West Yorkshire Partnership NHS Foundation Trust, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.