Human factor in the use of automated insulin delivery systems: Real-world effects in children with type 1 diabetes after 2 years of use (AID-A study)

Le résumé fourni par la source

AIMS: This study aimed to assess the metabolic effects, changes in daily life, and diabetes burden associated with automated insulin delivery (AID) systems in children in a real-world setting after 2 years of use. METHODS: Longitudinal glycaemic data (glycated haemoglobin [HbA1c], time in range [TiR], time below range [TbR], glucose management indicator [GMI]), body mass index (BMI), and AID system usage were collected from 111 children with type 1 diabetes at 12 and 24 months of AID use. After 1 year, adolescents and parents completed questionnaires on diabetes-related distress (P-PAID-C, P-PAID-T, and PAID-T) and experienced changes. RESULTS: Regardless of age or previous therapy, the HbA1c level decreased from 8.1 % (65 mmol/mol) to 7.7 % (61 mmol/mol), TiR increased from 55 % to 64 %, TbR decreased from 2.6 % to 1.8 %, and GMI (7.6 % vs. 7.3 %) improved after 1 year. After 2 years, HbA1c (7.6 % [60 mmol/mol]), TiR (62 %), TbR (1.3 %), and GMI (7.4 %) levels stabilised. Adolescents and parents reported improvements in daily life (i.e. sleep, stress, fear of hypoglycaemia). However, the BMI-SDS scores increased in the first year. CONCLUSIONS: AID system use is associated with clinically relevant improvements in glycaemic control and decrease in daily diabetes-related burden on affected children and their parents.

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