The “Two-Step Boost” for [ 177 Lu]Lu-PP-F11N Therapy: Optimization of Tumor Uptake by Premedication

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Interest in cholecystokinin-2 receptor (CCK2R)–targeted peptide receptor radiotherapy (PRRT) has recently increased. Enhanced expression of CCK2R on tumor cells was reported after inhibition of the mTORC1 pathway ([1][1]). Furthermore, there is clinical evidence that inhibition of endopeptidases