Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning

Le résumé fourni par la source

imaging of dorsal striatal neurons in head-fixed mice as they learned to self-initiate locomotion. We found that both direct- and indirect-pathway spiny projection neurons (dSPNs and iSPNs, respectively) exhibited robust activation during early locomotor bouts, with activity gradually diminishing across sessions. For dSPNs, action onset and offset ensembles progressively emerged from an initially broad population of nonspecific neurons. In contrast, iSPN ensembles originated from neurons responsive to opposing actions before refining into onset- or offset-specific populations. These findings demonstrate that striatal ensemble activity becomes more selective over time, with a reduction in nonspecific neuronal activation and an increase in the efficiency of striatal encoding for learned motor actions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.