Prognostic significance of body mass index in patients with triple negative breast cancer: A retrospective observational study
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Le résumé fourni par la source
Objectives Triple negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), making it more aggressive and less responsive to targeted therapies. Our retrospective study aimed to investigate the impact of body mass index (BMI) on the survival of TNBC patients in Eastern India. Material and Methods 42 TNBC patients were included from January 2016 to December 2020 and were followed up until December 2023. Baseline characteristics were summarized using percentages and frequencies. The Chi-square test was used for clinicopathologic characteristics, and the Kaplan-Meier method evaluated survival functions. Log-rank tests conducted (p ≤ 0.05). Results The median age of the population was 45 years. The majority (92.98%) had no family history. 67.7% were of Grade 2, and 27.69% were Grade 3. The mean BMI was 23.95 [ range 14.2 - 37.56 (95% CI 23.49;24.4)]. 62.81% were of a healthy weight, 28.51% were overweight, 4.55% were underweight, and 4.13% were obese. Metastasis-free survival (MFS) rates were 90.91% for underweight, 84.06% for overweight, 76.32% for healthy weight, and 70% for obese patients (p value .376). DFS, considering both local recurrence and metastases as an event, were 94.2% for overweight, 94.08% for healthy weight, 90% for obese, and 54.55% for underweight individuals (p value <0.001). OS was 65.22% for overweight, 61.84% for healthy weight, 60% for obese, and 30.36% for underweight individuals (p value 0.44). Conclusion This study’s findings highlight significant implications of BMI on survival outcomes. It also reinforces the intricate link between obesity and prognosis, emphasizing the need for weight management strategies in patient care. Further mechanistic research is warranted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prognostic significance of body mass index in patients with triple negative breast cancer: A retrospective observational study
- Date Crossref
- 04/09/2025
- Éditeur
- Scientific Scholar
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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R. G. Kar Medical College and Hospital pays non établi dans la noticeUniversité ou école supérieure
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Raiganj University pays non établi dans la noticeUniversité ou école supérieure
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Diamond Harbour Women's University pays non établi dans la noticeUniversité ou école supérieure
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Radha Gobinda Kar Medical College and Hospital Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Raiganj Government Medical College and Hospital Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Diamond Harbour Govt. Medical College and Hospital Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
R. G. Kar Medical College and Hospital, Raiganj University et Diamond Harbour Women's University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.