Association between multiple sclerosis and the risk of stroke: A population-based retrospective cohort study
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: Previous studies addressing the association between multiple sclerosis (MS) and stroke yielded conflicting results. The current study aimed to evaluate the association between MS and incident stroke, overall and by main stroke subtypes. METHODS: We conducted a population-based retrospective cohort study utilizing the Clalit Health Services database, the largest healthcare provider in Israel. The cohort included all incident MS patients aged ≥25 years diagnosed between 1 January 2005 and 31 December 2022. Each MS patient was matched to 10 non-MS controls based on age, sex, and population sector. MS cases (exposed group) and non-MS cases (unexposed group) were followed from the index date until 31 December 2023 for stroke occurrence. RESULTS: The study included 1602 MS patients and 16,020 non-MS controls. Overall stroke was diagnosed in 26 patients in the MS group and 233 in the non-MS group, reflecting a crude incidence rate of 1.61 and 1.40 per 1000 person-years, respectively. The adjusted hazard ratios (HRs) were 0.95 (95 % CI, 0.61-1.48) for overall stroke, 0.94 (95 % CI, 0.59-1.51) for ischemic stroke, and 0.94 (95 % CI, 0.25-3.56) for intracerebral hemorrhage. The results remained consistent when analysis was restricted to patients without a prior history of stroke, when follow-up was restricted to 2 years, and when the cohort was extended to include preexisting MS cases. Age and sex did not modify the association between MS and stroke risk (p-for interaction=0.161 and 0.647, respectively). CONCLUSIONS: Our findings suggest that MS is not associated with an increased risk of stroke.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association between multiple sclerosis and the risk of stroke: A population-based retrospective cohort study
- Date Crossref
- 01/11/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Technion – Israel Institute of Technology pays non établi dans la noticeUniversité ou école supérieure
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Carmel Medical Center Department of Community Medicine and Epidemiology pays non établi dans la noticeÉtablissement de santé
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Rappaport Family Institute for Research in the Medical Sciences pays non établi dans la noticeStructure de recherche
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University of Haifa pays non établi dans la noticeUniversité ou école supérieure
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Rabin Medical Center pays non établi dans la noticeÉtablissement de santé
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Ruth and Bruce Rappaport Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
Technion – Israel Institute of Technology, Department of Community Medicine and Epidemiology — Carmel Medical Center et Rappaport Family Institute for Research in the Medical Sciences, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.