Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study
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Le résumé fourni par la source
OBJECTIVES: To explore the prevalence and distribution of ultrasound-detected lesions indicating structural damage at the enthesis (e.g., bone erosions, enthesophytes, and calcifications) in patients with spondyloarthritis (SpA), comparing those with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and to investigate the demographic, clinical, and metabolic factors linked to these lesions. METHODS: A cross-sectional analysis was conducted using data from the DEUS study, a multicentre investigation involving 20 rheumatology centres and including 413 patients with SpA (224 with axSpA and 189 with PsA). All participants underwent standardized clinical and ultrasound assessment of the large lower limb entheses (quadriceps tendon, proximal and distal patellar tendons, Achilles tendon, and plantar fascia). Entheseal structural lesions were explored by ultrasound and classified according to OMERACT definitions. Bivariate analyses and multivariate logistic regression were used to assess associations between ultrasound lesions and SpA patients' characteristics. RESULTS: In SpA patients, enthesophytes were the most common lesion (78.7 %), followed by calcifications (43.6 %) and bone erosions (24.9 %). Enthesophytes were more prevalent in PsA (86.8 %) compared to axSpA (71.9 %) (p < 0.001), with no significant differences in erosions and calcifications. However, lesion distribution varied across different entheses. Multivariate analysis revealed that entheseal erosions were significantly associated with inflammatory markers, HLA-B27 positivity, clinical enthesitis, and longer disease duration. Enthesophytes were significantly linked to PsA, psoriasis, clinical enthesitis, and longer disease duration. Calcifications were positively associated with hypertension, metabolic syndrome, and obesity. All lesions were associated with biologic DMARD use. CONCLUSIONS: This study reveals a high prevalence of ultrasound-detected structural damage at the enthesis and identifies distinct SpA phenotypes based on these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study
- Date Crossref
- 01/10/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine pays non établi dans la noticeUniversité ou école supérieure
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NIHR Leeds Musculoskeletal Biomedical Research Unit pays non établi dans la noticeOrganisme public
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Marche Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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Ospedale di Parma pays non établi dans la noticeÉtablissement de santé
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University of Palermo Department of Health Promotion pays non établi dans la noticeUniversité ou école supérieure
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University of Cagliari pays non établi dans la noticeUniversité ou école supérieure
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Vall d'Hebron Hospital Universitari Rheumatology Unit pays non établi dans la noticeÉtablissement de santé
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Hacettepe University pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro Department of Precision and Rigenerative Medicine and Ionian Area (DiMePRe-J) Rheumatology Unit pays non établi dans la noticeUniversité ou école supérieure
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Hospital Juárez de México Rheumatology Department pays non établi dans la noticeÉtablissement de santé
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University Hospital in Motol pays non établi dans la noticeÉtablissement de santé
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University of Beira Interior University of Beira Interior, Mozambique (ville ou établissement reconnu, pays non nommé)Université ou école supérieure
Leeds Institute of Rheumatic and Musculoskeletal Medicine — University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit et Marche Polytechnic University, avec 9 autres affiliations. Pays d’affiliation : Mozambique.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.