Efficacy of melatonin and letrozole combination therapy compared to letrozole alone in the treatment of symptomatic endometrioma in infertile women
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Le résumé fourni par la source
Background: Endometriosis is an estrogen-driven inflammatory condition involving endometrial tissue growth outside the uterus. Letrozole, an aromatase inhibitor, lowers estrogen levels to reduce pain and lesion size. Melatonin offers additional benefits through its antioxidant, anti-inflammatory, and anti-proliferative effects on endometrial tissue. The present study was conducted to compare the effects of a combination of melatonin and letrozole with letrozole alone in infertile women with symptomatic endometrioma. Methods: This randomized controlled trial was conducted in the Department of Reproductive Endocrinology and Infertility of Bangabandhu Sheikh Mujib Medical University from July, 2023 to June, 2024. Total 40 infertile women with symptomatic endometrioma were included in this study. They were randomly allocated to receive either tab. letrozole 2.5 mg, twice daily plus tab. melatonin 3mg, 3 tablets at night daily or only tab. letrozole 2.5 mg, twice daily for 3 months. Results: Mean VAS score (6.88±2.39 vs 2.64±1.96) and mean size of endometrioma (3.77±1.22 vs 3.05±1.17 cm) were significantly decreased after 3 months of treatment with melatonin and letrozole combination therapy and mean VAS score (7.11±1.81 vs 3.22±1.89) and mean size of endometrioma (3.81±1.00 cm vs 3.27±0.85) were also significantly decreased after 3 months of treatment with letrozole alone group .But there were no statistically significant difference in terms of reducing pain score and size of endometrioma when compared between two groups. Conclusions: Melatonin and letrozole combination therapy compared to letrozole alone provide similar efficacy on symptomatic endometrioma in terms of reduction of pain score and size of endometrioma.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efficacy of melatonin and letrozole combination therapy compared to letrozole alone in the treatment of symptomatic endometrioma in infertile women
- Date Crossref
- 28/08/2025
- Éditeur
- Medip Academy
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bangladesh Shishu (Children) Hospital & Institute pays non établi dans la noticeÉtablissement de santé
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Bangladesh Shishu Hospital & Institute Department of Paediatric Surgery pays non établi dans la noticeOrganisme public
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Directorate General of Health Services pays non établi dans la noticeOrganisme public
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Comilla Medical College pays non établi dans la noticeÉtablissement de santé
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Bangladesh Medical University Department of Reproductive Endocrinology and Infertility pays non établi dans la noticeUniversité ou école supérieure
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Department of Obstetrics & Gynaecology pays non établi dans la noticeInstitution
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Department of Reproductive Endocrinology and Infertility pays non établi dans la noticeInstitution
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Cumilla Medical College Hospital Department of Obstetrics & Gynaecology pays non établi dans la noticeUniversité ou école supérieure
Bangladesh Shishu (Children) Hospital & Institute, Department of Paediatric Surgery — Bangladesh Shishu Hospital & Institute et Directorate General of Health Services, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.