Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region
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Le résumé fourni par la source
Objectives To estimate shared genetic susceptibility between major subtypes of idiopathic inflammatory myopathies (IIM) and B cell lymphomas. Methods We paired summary statistics from genome-wide association studies (GWASs) of diffuse large B cell lymphoma, follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma with those of dermatomyositis (DM) and polymyositis (PM) from a GWAS and an ImmunoChip study. We estimated local genetic correlation (r g ) for each disease pair using local analysis of (co)variant association (Bonferroni-corrected p value<0.05) and identified genetic variants jointly associated with both diseases using pleiotropy-informed false discovery rate (conjunctional false discovery rate <0.05). Functional mapping and annotation analyses were also performed. Results We identified significant r g (ranging from −0.50 to 0.84) across 16 loci, with half located in the human leucocyte antigen (HLA) region, for the disease pairs of IIM and B cell lymphoma subtypes. Furthermore, jointly associated single-nucleotide polymorphisms were predominantly found in the HLA region. Specifically, all disease pairs showed shared genetic susceptibility in the HLA class I regions, while additional correlations in class III and class II regions were specific to DM and PM disease pairs, respectively. For some non-HLA loci with significant r g , functional analyses revealed immune-related responses potentially overlapping between DM and FL, DM and CLL, and PM and CLL. Conclusion We revealed that DM and PM share genetic susceptibility with common B cell lymphoma subtypes in both immune-related loci and loci with unclear biological functions. These novel findings improve our understanding of the pathological link between IIM and B cell lymphomas.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region
- Date Crossref
- 01/07/2025
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Macau pays non établi dans la noticeUniversité ou école supérieure
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Karolinska Institutet Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Baylor College of Medicine Institute for Clinical and Translational Research pays non établi dans la noticeUniversité ou école supérieure
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Houston Institute for Clinical Research pays non établi dans la noticeStructure de recherche
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Karolinska University Hospital Theme Cancer pays non établi dans la noticeÉtablissement de santé
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Faculty of Health Sciences Department of Public Health and Medicinal Administration pays non établi dans la noticeUniversité ou école supérieure
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Clinical Epidemiology Division pays non établi dans la noticeÉtablissement de santé
University of Macau, Department of Medicine — Karolinska Institutet et Institute for Clinical and Translational Research — Baylor College of Medicine, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.