CGM profiling in Roux‐en‐Y gastric bypass, type 1 diabetes and healthy adults: Unmasking deviations from normoglycaemia

Le résumé fourni par la source

BACKGROUNDBariatric surgery such as Roux-en-Y gastric bypass (RYGB) is a cornerstone treatment for severe obesity, driving substantial weight loss and diabetes remission.1 However, the benefits on diabetes are tempered by the rising recognition of post-bariatric hypoglycaemia (PBH)-a late complication marked by hypoglycaemic episodes following rapid meal-induced glycaemic excursions. 2 Due to nonspecific symptoms, Continuous Glucose Monitoring (CGM)-which records interstitial glucose levels at 5-min intervals over 10-14 days-has become a vital screening tool for PBH detection and management.Yet interpreting CGM data in RYGB patients remains challenging: altered anatomy accelerates glucose absorption and amplifies GLP-1 responses, yielding faster glucose peaks and lower post-meal nadirs.While evaluation of glucose levels is often done with comparison against thresholds designed for people with diabetes, healthy non-operated individuals may confer the more suitable comparator to define deviation from "normal".However, such glycaemic benchmarks remain poorly characterised.This study directly addresses this gap by contrasting ambulatory CGM profiles from RYGB, type 1 diabetes, and healthy adults, matched for sex, age, and BMI, thereby delineating deviations from normal and diabetic glycaemic physiology.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.