Inflammation-based prognostic markers in renal cell carcinoma: insights from a 15-year experience
Rattachement africain : tr, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Renal cell carcinoma (RCC) represents nearly 90% of kidney cancers. With improvements in treatment and longer survival, reliable prognostic markers are increasingly important. This study investigated the prognostic value of systemic inflammatory markers and clinicopathological features in RCC patients undergoing nephrectomy. MATERIALS AND METHODS: We retrospectively analyzed 418 patients who underwent radical or partial nephrectomy for RCC between 2009 and 2024. Preoperative hematologic markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index (SII), were evaluated. Their associations with overall survival (OS) and recurrence-free survival (RFS) were assessed using survival analyses and multivariate Cox regression. RESULTS: The cohort had a median age of 60.5 years and a median follow-up of 72.3 months. Elevated NLR, PLR, SIRI, SII, and reduced LMR were associated with worse OS and RFS. On multivariate analysis, age > 64.5 years, higher tumor grade, NLR ≥ 2.93, and LMR < 3.67 independently predicted poorer OS. CONCLUSIONS: Simple, routinely available preoperative inflammatory markers, particularly NLR and LMR, may serve as useful predictors of survival in RCC patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Inflammation-based prognostic markers in renal cell carcinoma: insights from a 15-year experience
- Date Crossref
- 26/08/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dokuz Eylül University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Usak University pays non établi dans la noticeUniversité ou école supérieure
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Education Training And Research pays non établi dans la noticeOrganisation à but non lucratif
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Uşak Education and Training Hospital Urology Derpatment pays non établi dans la noticeÉtablissement de santé
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Esref Pasa Hospital Urology Department pays non établi dans la noticeÉtablissement de santé
Department of Urology — Dokuz Eylül University, Usak University et Education Training And Research, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.