Neurologic Deterioration After Intravenous Thrombolysis Among Stroke Patients in Assiut University Hospitals

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Background: Cerebrovascular Disease is categorized in the ICD-11 as Acute focal neurological impairment due to focal infarction at one or more locations in the brain or retina, also known as a stroke. The risk of early neurological decline (END) after recanalization therapy is a major concern.Aim and Objectives: To investigate the prevalence of neurological deterioration in individuals with acute ischemic stroke who have received thrombolytic therapy.Subjects and Methods: This prospective study was conducted at the Neurology Department Stroke Unit, Assiut University Hospitals, Assiut, Egypt, and included all acute ischemic stroke individuals stated in the duration from 1/1/2021 to 31/12/2021Result: The survival rate was (93%), 69% of patients showed significant improvement in NIHSS and mRS at 24h, and progressive improvement within 7 days of follow-up, 27% showed no difference in NIHSS or mRS at 24h, 3 days, 7 days of follow-up, and 4% showed deterioration at follow-up points without significant changes in NIHSS & mRS. Also, 68% showed a significant reduction in mRS from baseline to one month of follow-up.Conclusion: Early neurological deterioration was prevalent among cases with acute ischemic stroke after successful recanalization, with an incidence rate of 10.1%.

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