Profiling the metabolome of adenomyosis-associated infertility patients to predict the pregnancy outcome of frozen embryo transfer
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Le résumé fourni par la source
Objective: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). Our goal is to create a metabolite-based clinical prediction model for pregnancy outcomes in adenomyosis-associated infertility. Methods: This prospective cohort study from the Reproductive Center at Peking University Third Hospital enrolled 94 infertile patients with adenomyosis and control (CTRL) patients undergoing FET. We divided these patients into four groups based on clinical pregnancy success: ADM-Success, ADM-Fail, CTRL-Success, and CTRL-Fail. We collected peripheral blood on the day of embryo transfer and analyzed metabolites using ultrahigh-performance liquid chromatography-tandem mass spectrometry. We compared metabolome differences among the four groups using bioinformatics and evaluated the diagnostic performance of metabolites for predicting pregnancy outcomes using receiver operating characteristic curves. Results: We found the metabolic differences between ADM-Success group and ADM-Fail group, and established a "5 metabolites + age" panel (5 metabolites combined with woman's age panel), which could effectively predict pregnancy outcomes of adenomyosis patients, and the area under the curve was 0.879 (P<0.001). The 5 metabolites included Androsterone, Propionic acid, Glycocholic acid, 2,6-Dihydroxypurine, Deoxycorticosterone. And this study explored the metabolic differences between adenomyosis group and control group. Conclusions: A "5 metabolites + age" panel could effectively predict pregnancy outcomes of adenomyosis patients who undergoing FET. There were notable differences in plasma metabolic profiles between adenomyosis-associated infertility and control patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Profiling the metabolome of adenomyosis-associated infertility patients to predict the pregnancy outcome of frozen embryo transfer
- Date Crossref
- 25/08/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Peking University Key Laboratory of Assisted Reproduction pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Education pays non établi dans la noticeOrganisme public
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Peking University Third Hospital pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Center for Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology pays non établi dans la noticeStructure de recherche
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Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest pays non établi dans la noticeStructure de recherche
Key Laboratory of Assisted Reproduction — Peking University, Ministry of Education et Peking University Third Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.