Decoding the sleep enigma: a proteomic mediation analysis linking healthy sleep patterns to lung cancer risk
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Le résumé fourni par la source
STUDY OBJECTIVES: The biological link between sleep patterns and lung cancer remains an enigma. This study aims to explore how healthy sleep patterns modulate lung cancer risk through proteomic mediation and develop a sleep-related biomarker panel. METHODS: This study utilized data from the UK Biobank, comprising 34 881 participants. We used a composite sleep score that considered the following five sleep behaviors: sleep duration, chronotype, insomnia, snoring, and daytime sleepiness (0-5 scores). Proteomic profiling measured 2862 proteins, which were then used to build proteomic signatures through logistic regression to identify significant proteins, followed by LASSO regression to select representative biomarkers for forming weighted signatures. Cox proportional hazards models and mediation analysis were employed to evaluate associations between sleep patterns, proteins, and lung cancer risk. RESULTS: Higher healthy sleep scores were significantly associated with reduced lung cancer risk, with hazard ratios (HR = 0.589, p = .046) for a score of 3 and (HR = 0.516, p = .013) for a score of 4. Similar trends were observed in non-small cell lung cancer and lung adenocarcinoma. Proteomic signature analysis revealed that protein signatures associated with healthy sleep scores had a protective effect against lung cancer (HR = 0.865, p < .001) and non-small cell lung cancer (HR = 0.863, p < .001). Additionally, mediation analysis identified 18 proteins with mediation proportions exceeding 10 per cent in the relationship between healthy sleep scores and lung cancer, with CXCL17 showing the highest mediation proportion. CONCLUSIONS: This study reveals a potential association between healthy sleep patterns and reduced lung cancer risk.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Decoding the sleep enigma: a proteomic mediation analysis linking healthy sleep patterns to lung cancer risk
- Date Crossref
- 23/08/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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First Affiliated Hospital of Guangzhou Medical University Department of Thoracic Surgery and Oncology pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of University of South China pays non établi dans la noticeÉtablissement de santé
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State Key Laboratory of Respiratory Disease pays non établi dans la noticeStructure de recherche
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Guangzhou Institute of Respiratory Health pays non établi dans la noticeStructure de recherche
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University of South China pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
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The First People's Hospital of Zhaoqing pays non établi dans la noticeÉtablissement de santé
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Shantou University pays non établi dans la noticeUniversité ou école supérieure
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Shantou University Medical College pays non établi dans la noticeUniversité ou école supérieure
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Sun Yat-sen University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Sun Yat-sen Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Oncology Medical Center pays non établi dans la noticeÉtablissement de santé
Department of Thoracic Surgery and Oncology — First Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of University of South China et State Key Laboratory of Respiratory Disease, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.