Physical exercise modulates plasma irisin levels in endurance athletes: Implications for Parkinson's disease
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Le résumé fourni par la source
Physical exercise (PE) improves clinical outcomes in individuals with Parkinson's disease (PD) through unclear mechanisms. Irisin, a neuroprotective protein released by myocytes during PE, may play a role, but in vivo data in PD are limited. We investigated plasma irisin in a unique PD population engaged in chronic, intense PE. Ninety-three participants were classified based on both disease status (PD versus healthy controls, HC), and PE level (sedentary versus endurance athletes). Endurance athletes included subjects regularly participating in endurance sports (triathlon/long-distance marathon/cycling) for at least 5 years, with an average training duration of 1.5 h/day, 6 days/week. Four groups were generated: PD-Sedentary (PD-SD, n = 30), PD-Endurance Athletes (PD-EA, n = 15), HC-Sedentary (HC-SD, n = 30), and HC-Endurance Athletes (HC-EA, n = 18). Clinical and demographic features were collected. Plasma irisin was dosed in all groups. PD-EA had a longer disease duration compared to PD-SD (p = 0.005) but scored better on both MDS-UPDRS-part III (p = 0.029) and MMSE (p = 0.016). Plasma irisin was lower in endurance athletes versus sedentary participants regardless of disease status (PD-EA vs PD-SD, p = 0.002; PD-EA vs HC-SD, p = 0.003; HC-EA vs HC-SD, p = 0.046; HC-EA vs PD-SD, p = 0.029). In PD-SD plasma irisin positively correlated with MDS-UPDRS-part III (r = 0.395, p = 0.034), HY (r = 0.386, p = 0.042), and LEDD (r = 0.385, p = 0.043). Lower plasma irisin levels were associated with male sex (p < 0.001). Our findings suggest that chronic, intense PE ameliorates the neurological symptoms in individuals with PD, while differently modulating plasma irisin in a sex-dependent fashion. Irisin might mediate the beneficial clinical effects of PE, though further investigation is warranted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Physical exercise modulates plasma irisin levels in endurance athletes: Implications for Parkinson's disease
- Date Crossref
- 01/10/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Pavia Department of Brain and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
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Foundation Center pays non établi dans la noticeOrganisation à but non lucratif
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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IRCCS Mondino Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Fondazione Policlinico Universitario A. Gemelli IRCCS Neurology Unit pays non établi dans la noticeÉtablissement de santé
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Department of Neuroscience pays non établi dans la noticeInstitution
Department of Brain and Behavioral Sciences — University of Pavia, Foundation Center et Università Cattolica del Sacro Cuore, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.