Understanding and Managing Iatrogenic Withdrawal Syndrome in Adult Critically ill Patients: A Comprehensive Review

Résumé fourni par la source

Abstract Iatrogenic withdrawal syndrome (IWS) is increasingly recognized in adult critically ill patients. It results from prolonged use of opioids, benzodiazepines, and other medications, such as dexmedetomidine, propofol, and neuromuscular blocking agents. Patients with trauma, acute respiratory distress syndrome, and concomitant use of medications that may cause IWS are at increased risk. IWS can lead to negative outcomes like prolonged mechanical ventilation, extended ICU stay, and increased healthcare costs. Standardized prevention and management guidelines are lacking, and evidence for IWS prevention and management is scarce and controversial. This review addresses the risk factors and the different strategies for preventing and managing IWS in adult critically ill patients.

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