Ru(II)‐Based Photo‐Antibiotics: Light‐Driven Eradication of Bacterial Biofilm and Rapid Healing of Infective Wounds in Wistar Rat

Résumé fourni par la source

Abstract Three novel Ru(II)‐based photoantibiotics, viz ., [Ru(phtpy)(N,N,N) 2 ](PF 6 ) 2 , where N,N,N = 4′‐phenyl‐2,2′:6′,2″‐terpyridine (phtpy, Ru1 ), 4‐([2,2′:6′,2′′‐terpyridin]‐4′‐yl)‐ N , N ‐dimethylaniline (NMe 2 tpy, Ru2 ), trifluoromethylphenyl)‐2,2′:6′,2′′‐terpyridine (CF 3 tpy, Ru3 ) were developed with excellent photostability for visible light‐activated antibacterial activities and infective wound healing. Ru1‐Ru3 exhibited an absorption in the 400–600 nm range, beneficial for antibacterial photodynamic therapy (aPDT) application. Upon visible light exposure (400‐700 nm), Ru1‐Ru3 inhibited bacterial growth of Escherichia coli ( E. coli ), Staphylococcus aureus (S. aureus), and Bacillus subtilis (B. subtilis) , due to the effects of oxidative stress via ROS generation and photo‐oxidation of NADH. Ru3 was identified as a lead antibiotic that further showed antibiofilm activities against E. coli under visible light exposure. Ru3 was found to be biocompatible against rat red blood cells and human embryonic kidney cells. Ru3 + light promoted rapid healing of infected wounds within 9 days in an E. coli ‐induced rat model, highlighting its potential future use in healthcare.

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