Systematic review of electron transfer study in DNA relevant to Parkinson’s disease and scanning tunneling microscopy
Rattachement africain : my, ru, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Parkinson's disease (PD) is the most typical neurological disorder associated with aging in humans. Since PD has much to do with the medical field, most research studies focus on the biological, chemical, and medical aspects of the investigations, in addition to epidemiological studies, drug intervention studies, and much more. The lack of studies using scanning tunneling microscopy (STM) to investigate the electron transfer properties of DNA in PD opens up a new opportunity to look at electron transfer, which is fundamental to understanding the biological processes of the damage-repair mechanism of DNA in this disease, from a physical perspective. Hence, this systematic review was conducted to identify the methods or techniques currently used in the medical-related fields to study electron transfer in PD. related to electron transfer and PD. Methodology: Scopus, ScienceDirect, and EBSCOhost MEDLINE databases were used to search for literature related to electron transfer and PD. Results: From the thirty studies identified, PD appears to be caused by various causes, including increased levels of cytochrome c, reactive oxygen species produced by the mitochondria, dysfunction of complex I that interferes with the electron transfer process, and mitochondrial dysfunction triggered by PINK1 mutation. 6.7% of prior research has focused on utilizing DNA as a specific sample for investigating electron transfer in synthetic DNA through the use of STM. This highlights a notable lack of research into the potential of DNA in PD, despite the theoretical advantages that STM offers. Conclusions: We propose using STM as a new technique to study electron transfer in the DNA of PD from the physics perspective.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Systematic review of electron transfer study in DNA relevant to Parkinson’s disease and scanning tunneling microscopy
- Date Crossref
- 20/08/2025
- Éditeur
- PeerJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universiti Sains Malaysia pays non établi dans la noticeUniversité ou école supérieure
-
Physical Sciences Division pays non établi dans la noticeOrganisme public
-
RIKEN Nishina Center pays non établi dans la noticeStructure de recherche
-
Hospital Universiti Sains Malaysia pays non établi dans la noticeÉtablissement de santé
-
School of Medical Sciences Brain and Behaviour Cluster pays non établi dans la noticeUniversité ou école supérieure
-
Meson Science Laboratory pays non établi dans la noticeStructure de recherche
-
School of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
-
USM-RIKEN Interdisciplinary Collaboration for Advanced Sciences pays non établi dans la noticeInstitution
-
School of Distance Education pays non établi dans la noticeUniversité ou école supérieure
Universiti Sains Malaysia, Physical Sciences Division et RIKEN Nishina Center, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.