Novel Insight into Dugong Mortality: First Report of Systemic Achromobacter xylosoxidans Infection, Disseminated Intravascular Coagulation, and Associated Pathogenesis
Rattachement africain : th. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Dugongs (Dugong dugon), classified as vulnerable marine mammals, are increasingly impacted by infectious diseases, yet the role of septicemia and disseminated intravascular coagulation (DIC) in their mortality remains uncharacterized. This study aimed to investigate the pathological and microbiological features associated with an acute mortality event in a juvenile dugong during rehabilitation in southern Thailand. Comprehensive histopathological and microbiological analyses were conducted on tissue samples collected postmortem. Bacterial isolation and identification were performed using standard culture techniques and the VITEK-2 system. Histological examination revealed multisystemic lesions, including fibrin thrombi, hemorrhage, hepatocellular degeneration, pancreatic necrosis, lymphoid depletion, and neuronal damage. Oxidative stress and DNA damage were confirmed in brain tissues through immunofluorescence detection of 4-hydroxynonenal (4-HNE) and 8-hydroxy-2′-deoxyguanosine (8-oxodG). Achromobacter xylosoxidans, an opportunistic pathogen, was isolated from multiple organs, consistent with acute systemic infection. These findings represent the first evidence of septicemia-associated DIC in dugongs caused by A. xylosoxidans, highlighting a previously undocumented cause of mortality in dugongs. The results emphasize the role of opportunistic bacteria in triggering oxidative damage and coagulopathy and underscore the importance of early detection and targeted therapeutic strategies to improve survival in stranded or rehabilitated dugongs.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Novel Insight into Dugong Mortality: First Report of Systemic Achromobacter xylosoxidans Infection, Disseminated Intravascular Coagulation, and Associated Pathogenesis
- Date Crossref
- 20/08/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kasetsart University pays non établi dans la noticeUniversité ou école supérieure
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Department of Marine and Coastal Resources pays non établi dans la noticeOrganisme public
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Prince of Songkla University Dugong and Seagrass Research Station pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Marine and Coastal Resources Research Center (Lower Andaman Sea) pays non établi dans la noticeStructure de recherche
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Marine and Coastal Resources Research Center (Lower Gulf of Thailand) pays non établi dans la noticeStructure de recherche
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Faculty of Veterinary Science pays non établi dans la noticeUniversité ou école supérieure
Kasetsart University, Department of Marine and Coastal Resources et Dugong and Seagrass Research Station — Prince of Songkla University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.