Third-generation computed tomography angiography after coronary chronic total occlusion intervention in ruling out significant in-stent restenosis at long-term follow-up

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Background Invasive coronary angiography (ICA) is the gold standard in evaluating stent patency after percutaneous coronary intervention (PCI), but it carries a risk of potentially life-threatening complications. Third-generation coronary computed tomography angiography (CCTA) offers a non-invasive, safer follow-up method, but real-world data are lacking. This study evaluated the ability of CCTA to rule out in-stent restenosis (ISR) in long stents at long-term follow-up.Methods This prospective, single-center study (NCT06543641) included consecutive patients treated with PCI for coronary chronic total occlusion with long stents (LAD and RCA ≥38 mm, LCX ≥30 mm) in 2014–2019. All patients underwent third-generation dual-source CCTA. Patients with CCTA showing significant ISR, inconclusive results, or symptomatic native artery lesions underwent ICA.Results The study included 45 patients (median age 67 (IQR 62–73) years, 87% males) with 47 stents (median length 51 mm, range 36–132 mm). CCTA ruled out significant ISR in 87% (n = 39) of the patients. CCTA indicated 5 ISRs and 1 inconclusive result in 6 (13%) patients, all of whom underwent ICA. Additionally, ICA was conducted for 5 patients due to a native artery lesion(s) on CCTA and angina. ICA showed significant stenosis in all 6 patients (100%) with ISR or inconclusive CCTA finding in the long stent.Conclusion Third-generation CCTA could rule out significant ISR in a vast majority of cases (87%, n = 39) and without a risk of complications associated with ICA. CCTA provides a non-invasive, lower risk method for long-term revascularisation follow-up.

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