Dual-Action Antimicrobials: Prenylated Flavonoids from Paper Mulberry Fruit Targeting Staphylococcus aureus Fatty Acid Synthesis
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Le résumé fourni par la source
Paper mulberry ( Broussonetia papyrifera ) fruit, known for its flavor and health benefits, has previously been reported to exhibit antimicrobial activity, but its potential antibacterial effect against Staphylococcus aureus remains underexplored. This study investigated the anti- Staphylococcal activity of prenylated phenolics isolated from paper mulberry, including two novel compounds. Among these compounds, broussoflavonol B exhibited the strongest antibacterial activity against S. aureus CMCC 26003, with a minimum inhibitory concentration (MIC) of 6.9 µM. Mechanistic studies revealed that broussoflavonol B disrupted the cell structure and significantly reduced the levels of unsaturated fatty acids in bacterial cells. Additionally, it suppressed the expression of genes involved in fatty acid biosynthesis, maintaining its antibacterial effect even in the presence of exogenous fatty acids. Interestingly, all prenylated flavonoids from paper mulberry retained their antimicrobial activity in the presence of exogenous fatty acids, whereas prenylated phenopyran (papyriphenol) did not. This suggests a special mode of action for prenylated flavonoids, possibly involving the inhibition of phosphotransacetylase C (PlsC), as supported by molecular docking studies. In summary, the dual inhibitory effects of prenylated flavonoids from paper mulberry fruit provide a novel approach to combat S. aureus . By targeting multiple pathways, these compounds may offer a potential solution to the growing problem of antimicrobial resistance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dual-Action Antimicrobials: Prenylated Flavonoids from Paper Mulberry Fruit Targeting Staphylococcus aureus Fatty Acid Synthesis
- Date Crossref
- 01/08/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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South China Botanical Garden pays non établi dans la noticeStructure de recherche
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University of Chinese Academy of Sciences pays non établi dans la noticeUniversité ou école supérieure
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China National Botanical Garden pays non établi dans la noticeInstitution
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Universiti Tunku Abdul Rahman pays non établi dans la noticeUniversité ou école supérieure
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Centre for Biomedical and Nutrition Research pays non établi dans la noticeInstitution
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Faculty of Science Department of Allied Health Sciences pays non établi dans la noticeUniversité ou école supérieure
South China Botanical Garden, University of Chinese Academy of Sciences et China National Botanical Garden, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.