Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile
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Le résumé fourni par la source
PURPOSE: The Kun-Qi birth cohort (KQBC) was established to investigate the incidence, aetiology and risk factors of chronic kidney disease (CKD) in early childhood (0-6 years). Additionally, the study analysed developmental phenotypic trajectories and their associated paediatric diseases. PARTICIPANTS: Infants registered or residing in Kunshan and Qidong, Jiangsu Province, who participated in the Chinese Child Healthcare Programme (0-6 years) were enrolled. The baseline population was stratified into enhanced and basic cohorts. General characteristics, periconceptional and perinatal information and health check-up data were collected from each participant. Dual screening (urinary ultrasound and urine dipstick tests) was conducted during scheduled check-ups. Structured CKD questionnaires were administered, and biosamples (urine and dried blood spots) were obtained for the long-term storage and analysis using standard procedures. Based on the proposed referral procedure, participants with abnormal results were referred for further diagnosis and evaluation. FINDINGS TO DATE: The KQBC enrolled 10 127 infants (5392 boys and 4735 girls) with a mean age of 2.11±1.68 months. Urinary system ultrasound and urine dipstick screening showed positivity rates of 8.9% (900/10 083) and 6.5% (532/8233), respectively. Baseline ultrasound screening facilitated timely surgical intervention in six children. Among the 7965 respondents, only 13% demonstrated awareness of paediatric CKD. Additionally, 7273 dried blood spots and 7990 urine specimens were collected and stored. A paediatric CKD screening platform was developed. FUTURE PLANS: According to our plan, the KQBC will be followed up for 3-6 years to investigate the incidence, aetiology and risk factors of early onset CKD. In-depth developmental phenotypes, such as urinary multiomics and ultrasound imaging, should be studied for longitudinal paediatric kidney health. We aim to develop multimodal risk prediction models by integrating genomics and artificial intelligence algorithms. The KQBC also enables prospective cohort studies addressing extensive research questions. TRIAL REGISTRATION NUMBER: NCT06018831.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile
- Date Crossref
- 01/08/2025
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kidney Research UK pays non établi dans la noticeOrganisation à but non lucratif
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Children's Hospital of Fudan University Department of Nephrology pays non établi dans la noticeÉtablissement de santé
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Jiangsu University pays non établi dans la noticeUniversité ou école supérieure
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Kunming Children's Hospital pays non établi dans la noticeÉtablissement de santé
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First People's Hospital of Kunshan pays non établi dans la noticeÉtablissement de santé
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Shanghai Jiao Tong University Clinical Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Fudan University Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
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State Key Laboratory of Genetic Engineering pays non établi dans la noticeStructure de recherche
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Zhongshan Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai Kidney Development and Paediatric Kidney Disease Research Center pays non établi dans la noticeStructure de recherche
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and School of Life Sciences State Key Laboratory of Genetic Engineering pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Kidney Research UK, Department of Nephrology — Children's Hospital of Fudan University et Jiangsu University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.