A Comparative Study on the Efficacy of Intradermal Tranexamic Acid Versus Fluocinolone-Based Triple Combination Therapy in the Treatment of Melasma: A Randomized Controlled Trial
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Le résumé fourni par la source
Background: Melasma is a common, acquired hyperpigmentation disorder characterized by brown or gray-brown macules primarily on the face. Current treatment options for melasma include topical agents and intradermal therapies. This study compares the efficacy and safety of intradermal tranexamic acid (TA) and fluocinolone-based triple combination therapy (hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%) in 215 patients diagnosed with melasma. Objective: To evaluate and compare the efficacy and safety of intradermal TA versus fluocinolone-based triple combination therapy in the management of melasma. Methods: A randomized controlled trial was conducted with 215 patients, who were randomly assigned to receive either intradermal TA injections (100 mg) every 2 weeks for 12 weeks or topical fluocinolone-based triple combination therapy. The primary outcome was the change in the Melasma Area and Severity Index (MASI) score from baseline to week 12. Secondary outcomes included patient satisfaction and adverse effects. Results: Both treatments led to significant improvement in MASI scores. However, intradermal TA demonstrated a statistically greater reduction in MASI scores compared to the triple combination therapy (mean MASI reduction: TA = 8.5 vs. triple combination = 6.3, p < 0.05). Patient satisfaction was higher in the intradermal TA group, with fewer reported side effects such as skin irritation. Conclusion: Intradermal tranexamic acid is more effective and safer than the fluocinolone-based triple combination therapy in the treatment of melasma, offering a promising alternative with a superior safety profile. Keywords: Melasma, Intradermal Tranexamic Acid, Fluocinolone-Based Triple Combination Therapy, Hydroquinone, Tretinoin, Clinical Trial, MASI, Pigmentation Disorder
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Comparative Study on the Efficacy of Intradermal Tranexamic Acid Versus Fluocinolone-Based Triple Combination Therapy in the Treatment of Melasma: A Randomized Controlled Trial
- Date Crossref
- 11/01/2023
- Éditeur
- Lahore Medical and Dental College
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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CMH Lahore Medical College and Institute of Dentistry pays non établi dans la noticeÉtablissement de santé
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Rawalpindi Medical University pays non établi dans la noticeÉtablissement de santé
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Kidney Centre pays non établi dans la noticeÉtablissement de santé
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Services Hospital Endocrinology pays non établi dans la noticeÉtablissement de santé
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Government of Pakistan pays non établi dans la noticeOrganisme public
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Ittefaq Hospital Consultant Endocrinologist pays non établi dans la noticeÉtablissement de santé
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Azra Naheed Medical and Dental College Lahore Associate Professor of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Akhtar Saeed Medical College Rawalpindi Assistant Professor of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Pakistan Kidney Liver Institute Consultant Endocrinologist pays non établi dans la noticeStructure de recherche
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Federal Government Poly Clinic Islamabad Assistant Professor of Dermatology pays non établi dans la noticeÉtablissement de santé
CMH Lahore Medical College and Institute of Dentistry, Rawalpindi Medical University et Kidney Centre, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.