Household air pollution and blood pressure among adult women participants of the Household Air Pollution Intervention Network Trial: An exposure-response analysis

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BACKGROUND: ), has been linked to higher blood pressure (BP). Few studies have examined this association in biomass-dependent settings. We seek to determine whether high exposure during a 16 month period was associated with an increase in BP among older adult women over the study period and to determine whether short-term increases in exposure were associated with higher coincident blood pressure. METHODS: , black carbon (BC), and carbon monoxide (CO) on 368 adult women (mean age 52) in four countries (Rwanda, Peru, Guatemala, and India). We considered short- and long-term associations, the latter measured by change in BP and the former in mixed models of repeated measures. FINDINGS: , where the highest quartile had a 1.6 mmHg increase in SBP versus the referent group (p = 0.05). We found no association with long-term exposure, nor between CO and BP. INTERPRETATION: associated with increased BP, consistent with past literature. The lack of long-term associations may have been due to insufficient follow-up. FUNDING: The study is registered with ClinicalTrials.gov (NCT02944682) and funded by the U.S. National Institutes of Health (1UM1HL134590) in collaboration with the Bill & Melinda Gates Foundation (OPP1131279).

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