Whole-genome resequencing unveils the phylogeographic coevolution of Oncomelania hupensis with Yangtze River dynamics in China
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Le résumé fourni par la source
The freshwater snail Oncomelania hupensis is the only intermediate host of Schistosoma japonicum and is currently mainly distributed in the middle and lower reaches of the Yangtze River in China. To explore the evolutionary history and adaptations of O. hupensis, we re-sequenced 283O. hupensis accessions from 30 geographic locations across the middle and lower Yangtze River. Our study raises and proves an intriguing hypothesis: O. hupensis has its distribution and adaptation closely tied to the geological evolution of the Yangtze River. Despite varying degrees of isolation and differentiation, lake-type snail populations in the middle and lower reaches may migrate westward to eastward (from middle to lower reaches) via water flow, while hill ecotype snails in the middle reaches potentially disperse from hilly region to lake areas. Population genetics and evolutionary analyses revealed that O. hupensis exhibits a gradual dispersal history from hilly region to downstream areas, closely mirroring the Yangtze River's flow and geological evolution. Compared to hill ecotype populations, lake populations displayed higher genetic diversity, consistent with dynamic habitats and increased gene flow. This west-to-east migration pattern may be driven by the Yangtze River's geological dynamics and associated climatic-ecological shifts. Notably, we found genes under strong positive selection differed between lake and hill ecotype populations. Our study provides comprehensive insights into the population dynamics and genetic architecture of O. hupensis, underscoring its coevolution with the Yangtze River's geological history. These findings advance the genetic understanding of O. hupensis adaptation to different ecological environments and inform schistosomiasis control strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Whole-genome resequencing unveils the phylogeographic coevolution of Oncomelania hupensis with Yangtze River dynamics in China
- Date Crossref
- 01/12/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institute for Parasitic Diseases pays non établi dans la noticeOrganisme public
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Inner Mongolia University pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Jiao Tong University Clinical Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Beijing Graphene Institute pays non établi dans la noticeStructure de recherche
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BGI Research pays non établi dans la noticeOrganisation à but non lucratif
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School of Life Sciences State Key Laboratory of Genetics and Development of Complex Phenotypes pays non établi dans la noticeUniversité ou école supérieure
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College of Life Sciences Institute of Biomedical Science pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Parasitic Diseases pays non établi dans la noticeStructure de recherche
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School of Global Health pays non établi dans la noticeUniversité ou école supérieure
National Institute for Parasitic Diseases, Inner Mongolia University et Clinical Research Institute — Shanghai Jiao Tong University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.