Coronary function testing vs angiography alone to guide treatment of angina with non-obstructive coronary arteries: the ILIAS ANOCA trial
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Le résumé fourni par la source
BACKGROUND AND AIMS: Invasive coronary function testing (CFT) identifies coronary vasomotor disorders in up to 90% of patients with angina with non-obstructive coronary arteries (ANOCA). The ILIAS ANOCA trial hypothesized that routine ad hoc CFT would be feasible, safe, and effective in providing an early, comprehensive diagnosis. Additionally, it was anticipated that combining CFT with a disease-specific treatment protocol would significantly improve quality of life in ANOCA patients compared with standard care. METHODS: After excluding patients with obstructive coronary artery disease (CAD) during clinically indicated invasive coronary angiography (ICA), eligible patients underwent CFT and were randomized to either the standard care group, where CFT results remained blinded, or the intervention group, where CFT results were disclosed along with a tailored medical therapy protocol. The primary outcome was the mean difference in the within-subject change in Seattle Angina Questionnaire summary score (SAQSS) between groups from baseline to a follow-up of 6 months. The trial is registered with the International Clinical Trials Registry Platform (NL-OMON20739). RESULTS: A total of 255 patients consented, of whom 153 patients (60%) without CAD underwent CFT and were randomized 1:1 to the standard care (n = 76) or intervention group (n = 77). All CFT procedures were successful without adverse events. A vasomotor disorder was identified in 120 patients (78%). At 6-month follow-up, the SAQSS improved significantly in the intervention group compared with the control group, with an intervention effect of 9.4 units (95% confidence interval 3.9-14.9, P = .001). There were no major adverse cardiac events at the 6-month follow-up. CONCLUSIONS: Routine CFT during the initial ICA was feasible, safe, and had high diagnostic yield. Implementing a pragmatic CFT protocol combined with a disease-specific treatment protocol significantly improved disease-related quality of life in patients with ANOCA compared with standard care.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Coronary function testing vs angiography alone to guide treatment of angina with non-obstructive coronary arteries: the ILIAS ANOCA trial
- Date Crossref
- 12/08/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Amsterdam University Medical Centers Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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University of Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Heidelberg pays non établi dans la noticeÉtablissement de santé
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University Medical Center Utrecht Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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European Patent Organisation pays non établi dans la noticeInstitution
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Amphia Ziekenhuis pays non établi dans la noticeÉtablissement de santé
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Robert Bosch Hospital pays non établi dans la noticeÉtablissement de santé
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Golden Jubilee National Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
Department of Cardiology — Amsterdam University Medical Centers, University of Amsterdam et Heidelberg University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.