Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine
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Le résumé fourni par la source
The war-related migrations from Ukraine to Poland have resulted in an increased prevalence of individuals diagnosed with human immunodeficiency virus type 1 (HIV-1) A6 variant. We examined the impact of the influx of people living with HIV (PLWH) displaced from Ukraine on the emergence of transmission events and evolving patterns in the A6 epidemic in Poland. We created a dataset of 13,696 unique HIV-1 pol gene fragments of sub-subtype A6 including 1,889 sequences from Poland. To evaluate the import of distinct clusters and estimate dispersal dynamics, we performed time calibration of the maximum-likelihood phylogenetic trees and phylogeographic inferences using the software package BEAST with discrete and continuous diffusion models. Our results indicated that A6 infections among males predominated within the domestic population (76.1%, n = 1,437), primarily within large clusters. Among Ukrainian migrants, 69.5% of the cases occurred as singletons or dyads (n = 473; p < 0.0001) with a balanced male-to-female ratio of 1.1. Since the war, the contribution of HIV-acquired individuals born in Ukraine to the virus circulation in Poland has increased to 30.2%, with an additional 334 distinct A6 introductions, inferred as internal nodes and descendant clusters that likely entered Poland from other countries. These migration events were concentrated in the central regions with a higher HIV prevalence. After the war outbreak in 2022, the number and complexity of A6 transmission chains in Poland expanded, driven by male-dominated domestic clusters and war-related migration. Understanding the existence of two distinct transmission dynamics is critical for designing targeted public health interventions. Halting national sub-subtype A6 circulation requires a combined approach that harmonizes the existing strategy focused on the men who have sex with men population with enhanced efforts to link migrants to care.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine
- Date Crossref
- 06/08/2025
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Pomeranian Medical University Department of Infectious pays non établi dans la noticeUniversité ou école supérieure
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Medical University of Warsaw Department of Infectious and Tropical Diseases and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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Cardinal Stefan Wyszynski University in Warsaw pays non établi dans la noticeUniversité ou école supérieure
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Medical University of Lodz pays non établi dans la noticeUniversité ou école supérieure
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Baltic Sea Cultural Centre in Gdańsk pays non établi dans la noticeInstitution
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Wroclaw Medical University Department of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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Jagiellonian University Department of Infectious and Tropical Diseases pays non établi dans la noticeUniversité ou école supérieure
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Nicolaus Copernicus University pays non établi dans la noticeUniversité ou école supérieure
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University of Zielona Góra pays non établi dans la noticeUniversité ou école supérieure
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University of Warmia and Mazury in Olsztyn pays non établi dans la noticeUniversité ou école supérieure
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Molecular Diagnostics Laboratory pays non établi dans la noticeStructure de recherche
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Faculty of Medical Science pays non établi dans la noticeUniversité ou école supérieure
Department of Infectious — Pomeranian Medical University, Department of Infectious and Tropical Diseases and Hepatology — Medical University of Warsaw et Cardinal Stefan Wyszynski University in Warsaw, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.