Role of early peritoneal dialysis after neonatal arterial switch operation

Résumé fourni par la source

Objective: Peritoneal dialysis (PD) commenced early in the postoperative period has the potential to mitigate the postcardiopulmonary bypass inflammatory response. We evaluated the role of early PD on postoperative outcomes after the arterial switch operation (ASO). Methods: Newborns (≤30 days, n = 318) undergoing ASO were classified into those who did (early PD, n = 90) or did not (control, n = 228) receive PD within 6 hours of admission to intensive care unit after surgery. Using observational data and imitating a preplanned clinical trial (target trial framework), we evaluated the role of early PD on postoperative outcomes. Results: interaction <.001). Similar results were seen for intensive care unit length of stay. Conclusions: Early PD after ASO was associated with a reduction in duration of mechanical ventilation and intensive care stay for infants who required ECMO in the perioperative period. Future studies of early PD, ideally clinical trials, in high-risk infants (such as those requiring ECMO after cardiac surgery) will be of benefit to either confirm or refute these findings.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.