Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers
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Le résumé fourni par la source
BACKGROUND: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcomes in patients with DFUs. METHODS: In this non-randomized prospective study, 20 patients with ischemic DFUs were followed over a 36-month period. Fourteen received HBOT in addition to standard care, while six received standard care alone. Clinical outcomes-including DFU resolution, recurrence, lower extremity amputation (LEA), and mortality-were assessed alongside systemic inflammatory and angiogenic biomarkers and wound characteristics at baseline and at 3, 6, 12, and 36 months. CD31 immunostaining was performed on available tissue samples. RESULTS: < 0.05), with downward trends observed in C-reactive protein (CRP), vascular endothelial growth factor (VEGF), and placental growth factor (PlGF), and an increase in stromal-derived factor-1 alpha (SDF1-α). No significant changes were observed in the control group. CD31+ microvessel density appeared to increase in HBOT-treated DFU tissue after one month, although the sample size was limited. Patients receiving HBOT had lower rates of LEA and mortality, improved wound healing, and sustained outcomes over three years. DFU recurrence rates were similar between groups. CONCLUSIONS: HBOT was associated with improved wound healing and favorable biomarker profiles in patients with treatment-resistant ischemic DFUs. While these findings are encouraging, the small sample size and non-randomized design limit their generalizability, highlighting the need for larger, controlled studies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers
- Date Crossref
- 04/08/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fernando Pessoa University pays non établi dans la noticeUniversité ou école supérieure
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Universidade do Porto pays non établi dans la noticeUniversité ou école supérieure
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Instituto de Investigação Inovação e Desenvolvimento pays non établi dans la noticeStructure de recherche
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Universidade Católica Portuguesa Escola superior de Biotecnologia pays non établi dans la noticeUniversité ou école supérieure
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Centro de Biotecnologia e Química Fina pays non établi dans la noticeStructure de recherche
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Administração Regional de Saúde de Lisboa e Vale do Tejo pays non établi dans la noticeOrganisme public
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Hospital de Santo António pays non établi dans la noticeÉtablissement de santé
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Centro Hospitalar de Vila Nova de Gaia pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Bomedicine Department pays non établi dans la noticeUniversité ou école supérieure
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CECLIN—Centre of Clinical Studies pays non établi dans la noticeÉtablissement de santé
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University Fernando Pessoa FP-I3ID—Instituto de Investigação pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine and Biomedical Sciences RISE-Health pays non établi dans la noticeUniversité ou école supérieure
Fernando Pessoa University, Universidade do Porto et Instituto de Investigação Inovação e Desenvolvimento, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.